1: HomoloGene:21047. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PPARA,  Homo sapiens
peroxisome proliferator-activated receptor alpha
    NP_001001928.1
468 aa
Domain ImageDomain Image
   PPARA,  Pan troglodytes
peroxisome proliferator-activated receptor alpha
    XP_001136299.1
467 aa
Domain ImageDomain Image
   PPARA,  Canis lupus familiaris
peroxisome proliferator-activated receptor alpha
    NP_001003093.1
468 aa
Domain ImageDomain Image
   PPARA,  Bos taurus
peroxisome proliferator-activated receptor alpha
    NP_001029208.1
470 aa
Domain ImageDomain Image
   Ppara,  Mus musculus
peroxisome proliferator activated receptor alpha
    NP_035274.2
468 aa
Domain ImageDomain Image
   Ppara,  Rattus norvegicus
peroxisome proliferator activated receptor alpha
    NP_037328.1
468 aa
Domain ImageDomain Image
   PPARA,  Gallus gallus
peroxisome proliferator-activated receptor alpha
    NP_001001464.1
468 aa
Domain ImageDomain Image
   pparab,  Danio rerio
peroxisome proliferator activated receptor alpha b
    NP_001096037.1
459 aa
Domain ImageDomain Image


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenrate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.


  Homo sapiens
 
Hyperapobetalipoproteinemia, susceptibility to.
 
Mus musculus
 
Muscle phenotype.
 
Liver/biliary system phenotype.
 
Life span-post-weaning/aging.
 
Adipose tissue phenotype. The observable morphological and physiological characteristics of mammalian fat tissue that are manifested through development and lifespan.
 
Homeostasis/metabolism phenotype.
 
Growth/size phenotype.
 
Cardiovascular system phenotype. The observable morphological and physiological characteristics of the mammalian heart, blood vessels, or circulatory system that are manifested through development and lifespan.
 
Immune system phenotype.
 
Skin/coat/nails phenotype.



PubMed
Articles associated with genes and sequences of this entry plus additional related articles.

 
Caron-Dorval D, et al.
Effect of the PPAR-Alpha L162V polymorphism on the cardiovascular disease risk factor in response to n-3 polyunsaturated fatty acids. J Nutrigenet Nutrigenomics 1, 205-12(2008).
 
Combarros O, et al.
APOE dependent-association of PPAR-gamma genetic variants with Alzheimer's disease risk. Neurobiol Aging(2009).
 
Chakravarthy MV, et al.
Identification of a physiologically relevant endogenous ligand for PPARalpha in liver. Cell 138, 476-88(2009).
 
Gutgesell A, et al.
Mouse carnitine-acylcarnitine translocase (CACT) is transcriptionally regulated by PPARalpha and PPARdelta in liver cells. Biochim Biophys Acta 1790, 1206-16(2009).
 
Mazzon E, et al.
Role of peroxisome proliferator-activated receptor-alpha in ileum tight junction alteration in mouse model of restraint stress. Am J Physiol Gastrointest Liver Physiol 297, G488-505(2009).
 

 


Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.

 
zf-C4 (cl02596)
  Zinc finger, C4 type (two domains).
 
NR_LBD (cl11397)
  The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators.



Related Homology Resources
Links to curated and computed homology information found in other databases.

 
Orthology group for M.musculus Ppara includes H.sapiens PPARA and R.norvegicus Ppara.



UniGene
Links to groups of transcribed sequences established by tblastn searching of UniGene.

 
Peroxisome proliferator-activated receptor alpha
 
Peroxisome proliferator-activated receptor alpha
 
Peroxisome proliferator activated receptor alpha, like
 
Si:ch211-239e6.3
 
Peroxisome proliferator-activated receptor alpha
 
Transcribed locus, moderately similar to NP_005027.2 peroxisome proliferativ...
 
Peroxisome proliferator-activated receptor alpha
 
Peroxisome proliferator-activated receptor alpha
 
Peroxisome proliferator activated receptor alpha
 
Oryctolagus cuniculus peroxisome proliferator-activated receptor-alpha (PPAR...
 
Peroxisome proliferator-activated receptor alpha
 
Transcribed locus, moderately similar to XP_691755.2 PREDICTED: hypothetical...
 
Peroxisome proliferator activated receptor alpha
 
Peroxisome proliferator-activated receptor alpha
 
Peroxisome proliferator-activated receptor alpha
 
Peroxisome proliferators-activated receptor alpha2
 
Peroxisome proliferators-activated receptor alpha1
 
Peroxisome proliferator activated receptor alpha
 
Hypothetical LOC496107