Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.
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Proteins
Proteins used in sequence comparisons and their conserved domain architectures.
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ALAD, Homo sapiens
aminolevulinate, delta-, dehydratase |
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NP_000022.3
330 aa |
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ALAD, Pan troglodytes
aminolevulinate, delta-, dehydratase |
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XP_001152138.1
363 aa |
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ALAD, Canis lupus familiaris
aminolevulinate, delta-, dehydratase |
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XP_855370.1
330 aa |
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ALAD, Bos taurus
aminolevulinate, delta-, dehydratase |
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NP_001014895.1
329 aa |
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Alad, Mus musculus
aminolevulinate, delta-, dehydratase |
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NP_032551.3
330 aa |
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Alad, Rattus norvegicus
aminolevulinate, delta-, dehydratase |
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NP_037031.1
330 aa |
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zgc:110219, Danio rerio
zgc:110219 |
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NP_001017645.1
331 aa |
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Pbgs, Drosophila melanogaster
Porphobilinogen synthase |
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NP_648564.1
327 aa |
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AgaP_AGAP010935, Anopheles gambiae
AGAP010935-PA |
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XP_309759.4
328 aa |
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hem2, Schizosaccharomyces pombe
porphobilinogen synthase Hem2 (predicted) |
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NP_593917.1
329 aa |
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HEM2, Saccharomyces cerevisiae
Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus |
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NP_011475.1
342 aa |
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KLLA0F09273g, Kluyveromyces lactis
hypothetical protein |
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XP_455502.1
342 aa |
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AGOS_AGR015C, Eremothecium gossypii
AGR015Cp |
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NP_986680.1
340 aa |
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MGG_10655, Magnaporthe grisea
hypothetical protein |
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XP_366437.1
389 aa |
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NCU01013.1, Neurospora crassa
hypothetical protein |
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XP_326506.1
385 aa |
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HEMB1, Arabidopsis thaliana
HEMB1; catalytic/ metal ion binding / porphobilinogen synthase |
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NP_177132.1
430 aa |
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Os06g0704600, Oryza sativa
hypothetical protein |
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NP_001058510.1
426 aa |
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PF14_0381, Plasmodium falciparum
delta-aminolevulinic acid dehydratase |
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XP_001348555.1
451 aa |
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Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.
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Homo sapiens |
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Lead poisoning, susceptibility to. |
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Porphyria, acute hepatic. |
PubMed
Articles associated with genes and sequences of this entry plus additional related articles.
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Krieg EF Jr, et al.Lead and cognitive function in ALAD genotypes in the third National Health and Nutrition Examination Survey. Neurotoxicol Teratol 31, 364-71(2009). |
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Miyaki K, et al.Association between a polymorphism of aminolevulinate dehydrogenase (ALAD) gene and blood lead levels in Japanese subjects. Int J Environ Res Public Health 6, 999-1009(2009). |
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Sharmila Banu G, et al.Effects of leaves extract of Ocimum sanctum L. on arsenic-induced toxicity in Wistar albino rats. Food Chem Toxicol 47, 490-5(2009). |
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Shaik AP & Jamil K.A study on the ALAD gene polymorphisms associated with lead exposure. Toxicol Ind Health 24, 501-6(2008). |
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Chen Y, et al.Lack of association of delta-aminolevulinic acid dehydratase genotype with blood lead levels in environmentally exposed children of Uygur and Han populations. Acta Paediatr 97, 1717-20(2008). |
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Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
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ALAD_PBGS (cl00338) Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the... |
Related Homology Resources
Links to curated and computed homology information found in other databases.
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Orthology group for M.musculus Alad includes H.sapiens ALAD and R.norvegicus Alad. |
UniGene
Links to groups of transcribed sequences established by tblastn searching of UniGene.
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Strain Liverpool chromosome 2 |
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Transcribed locus, strongly similar to XP_309759.4 AGAP010935-PA [Anopheles ... |
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Similar to Delta-aminolevulinic acid dehydratase (Porphobilinogen synthase) ... |
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Transcribed locus, moderately similar to NP_001077800.1 HEMB1 [Arabidopsis t... |
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HEMB1; porphobilinogen synthase |
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HEMB2; porphobilinogen synthase |
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Transcribed locus, strongly similar to NP_001077800.1 HEMB1 [Arabidopsis tha... |
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Aminolevulinate, delta-, dehydratase |
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Transcribed locus, strongly similar to NP_001077800.1 HEMB1 [Arabidopsis tha... |
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Transcribed locus, strongly similar to NP_001077800.1 HEMB1 [Arabidopsis tha... |
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Transcribed locus, moderately similar to NP_001077800.1 HEMB1 [Arabidopsis t... |
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Transcribed locus, strongly similar to NP_001077800.1 HEMB1 [Arabidopsis tha... |
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Aminolevulinate, delta-, dehydratase |
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Delta-aminolevulinic acid dehydratase |
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Transcribed locus, moderately similar to NP_001077800.1 HEMB1 [Arabidopsis t... |
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Transcribed locus, moderately similar to NP_001077800.1 HEMB1 [Arabidopsis t... |
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Zgc:110219 |
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Porphobilinogen synthase |
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Similar to Delta-aminolevulinic acid dehydratase (Porphobilinogen synthase) ... |
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Similar to MGC84775 protein |
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Clone CFW156-C03 mRNA sequence |
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Transcribed locus, moderately similar to XP_326506.1 hypothetical protein [N... |
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Delta-aminolevulinic acid dehydratase |
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Transcribed locus, strongly similar to NP_001077800.1 HEMB1 [Arabidopsis tha... |
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Transcribed locus, moderately similar to NP_001077800.1 HEMB1 [Arabidopsis t... |
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Aminolevulinate, delta-, dehydratase |
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Transcribed locus, moderately similar to NP_001077800.1 HEMB1 [Arabidopsis t... |
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CDNA clone: FLbaf19c06, mRNA sequence |
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Transcribed locus, moderately similar to NP_001077800.1 HEMB1 [Arabidopsis t... |
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ALAD mRNA for aminolevulinate, delta-, dehydratase |
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Similar to delta-aminolevulinic acid dehydratase isoform b |
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MGG_10655 hypothetical protein |
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Transcribed locus, strongly similar to NP_001077800.1 HEMB1 [Arabidopsis tha... |
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Transcribed locus, moderately similar to NP_001077800.1 HEMB1 [Arabidopsis t... |
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Transcribed locus, weakly similar to NP_037031.1 aminolevulinate, delta-, de... |
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Aminolevulinate, delta-, dehydratase |
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Transcribed locus, moderately similar to NP_001077800.1 HEMB1 [Arabidopsis t... |
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Transcribed locus, moderately similar to NP_001017645.1 hypothetical protein... |
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Os06g0704600 |
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Transcribed locus, moderately similar to NP_001017645.1 hypothetical protein... |
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Transcribed locus, strongly similar to NP_001014895.1 hypothetical protein L... |
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Transcribed locus, strongly similar to XP_001192204.1 PREDICTED: similar to ... |
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GSPATT00010579001 hypothetical protein |
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Transcribed locus, weakly similar to NP_001077800.1 HEMB1 [Arabidopsis thali... |
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Transcribed locus, moderately similar to NP_001077800.1 HEMB1 [Arabidopsis t... |
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5-aminolevulinate dehydratase |
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Transcribed locus, moderately similar to NP_001077800.1 HEMB1 [Arabidopsis t... |
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Transcribed locus, moderately similar to NP_001077800.1 HEMB1 [Arabidopsis t... |
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Transcribed locus, strongly similar to NP_001017645.1 hypothetical protein L... |
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Transcribed locus, moderately similar to NP_001077800.1 HEMB1 [Arabidopsis t... |
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Transcribed locus, moderately similar to NP_001077800.1 HEMB1 [Arabidopsis t... |
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Transcribed locus, strongly similar to NP_001077800.1 HEMB1 [Arabidopsis tha... |
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Aminolevulinate dehydratase (alad) |
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Aminolevulinate, delta-, dehydratase |
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Transcribed locus, strongly similar to NP_001058510.1 Os06g0704600 [Oryza sa... |
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Transcribed locus, strongly similar to NP_001017645.1 hypothetical protein L... |
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Aminolevulinic acid dehydratase mRNA |
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Transcribed locus, strongly similar to NP_001077800.1 HEMB1 [Arabidopsis tha... |
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Transcribed locus, strongly similar to NP_001058510.1 Os06g0704600 [Oryza sa... |
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Similar to delta-aminolevulinate dehydratase; porphobilinogen synthase |
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Transcribed locus, strongly similar to NP_000022.2 delta-aminolevulinic acid... |
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Delta-aminolevulinic acid dehydratase |
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Delta-aminolevulinic acid dehydratase isoform 1 (HemB) |
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Transcribed locus, strongly similar to XP_001363909.1 PREDICTED: similar to ... |
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Transcribed locus, moderately similar to NP_001058510.1 Os06g0704600 [Oryza ... |
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Transcribed locus, strongly similar to NP_001058510.1 Os06g0704600 [Oryza sa... |
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Transcribed locus, moderately similar to NP_001077800.1 HEMB1 [Arabidopsis t... |
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Delta-aminolevulinic acid dehydratase |
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MGC84775 protein |
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MGC83017 protein |
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Transcribed locus, strongly similar to NP_001058510.1 Os06g0704600 [Oryza sa... |
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