Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.
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Proteins
Proteins used in sequence comparisons and their conserved domain architectures.
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AGA, Homo sapiens
aspartylglucosaminidase |
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NP_000018.1
346 aa |
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AGA, Pan troglodytes
aspartylglucosaminidase |
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XP_517545.2
346 aa |
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AGA, Canis lupus familiaris
aspartylglucosaminidase |
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XP_532851.2
343 aa |
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Aga, Mus musculus
aspartylglucosaminidase |
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NP_001005847.1
346 aa |
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Aga, Rattus norvegicus
aspartylglucosaminidase |
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NP_001026811.1
345 aa |
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AGA, Gallus gallus
aspartylglucosaminidase |
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NP_001006445.1
345 aa |
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aga, Danio rerio
aspartylglucosaminidase |
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NP_001103751.1
337 aa |
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CG1827, Drosophila melanogaster
CG1827, isoform C |
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NP_610504.2
393 aa |
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CG10474, Drosophila melanogaster
CG10474 |
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NP_611404.1
341 aa |
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AgaP_AGAP012301, Anopheles gambiae
AGAP012301-PA |
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XP_320240.4
361 aa |
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glycosylasparaginase, Caenorhabditis elegans
hypothetical protein |
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NP_508448.1
363 aa |
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MGG_03346, Magnaporthe grisea
hypothetical protein |
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XP_360803.2
323 aa |
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NCU09718.1, Neurospora crassa
hypothetical protein |
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XP_330368.1
314 aa |
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AT5G61540, Arabidopsis thaliana
L-asparaginase, putative / L-asparagine amidohydrolase, putative |
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NP_200962.2
359 aa |
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Os04g0549300, Oryza sativa
hypothetical protein |
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NP_001053482.1
387 aa |
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Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.
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Homo sapiens |
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Aspartylglucosaminuria. |
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Mus musculus |
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Nervous system phenotype. |
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Renal/urinary system phenotype. |
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Liver/biliary system phenotype. |
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Life span-post-weaning/aging. |
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Homeostasis/metabolism phenotype. |
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Growth/size phenotype. |
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Cellular phenotype. |
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Behavior/neurological phenotype. The observable actions or reactions of mammalian organisms that are manifested through development and lifespan. |
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Skin/coat/nails phenotype. |
PubMed
Articles associated with genes and sequences of this entry plus additional related articles.
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Michelakakis H, et al.Plasma lysosomal enzyme activities in congenital disorders of glycosylation, galactosemia and fructosemia. Clin Chim Acta 401, 81-3(2009). |
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Saito S, et al.Structural basis of aspartylglucosaminuria. Biochem Biophys Res Commun 377, 1168-72(2008). |
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Jackson M, et al.Elevation of plasma aspartylglucosaminidase is a useful marker for the congenital disorders of glycosylation type I (CDG I). J Inherit Metab Dis 28, 1197-8(2005). |
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Saarela J, et al.A novel aspartylglucosaminuria mutation affects translocation of aspartylglucosaminidase. Hum Mutat 24, 350-1(2004). |
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Kelo E, et al.Massive accumulation of Man2GlcNAc2-Asn in nonneuronal tissues of glycosylasparaginase-deficient mice and its removal by enzyme replacement therapy. Glycobiology 15, 79-85(2005). |
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Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
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Ntn_Asparaginase_2_like (cl00635) Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked... |
Related Homology Resources
Links to curated and computed homology information found in other databases.
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Orthology group for M.musculus Aga includes H.sapiens AGA and R.norvegicus Aga. |
UniGene
Links to groups of transcribed sequences established by tblastn searching of UniGene.
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Strain Liverpool chromosome 3 |
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Transcribed locus, strongly similar to XP_320240.4 AGAP012301-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_320240.2 ENSANGP00000016583 [Anoph... |
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Transcribed locus, strongly similar to XP_320240.2 ENSANGP00000016583 [Anoph... |
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Similar to N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase precursor (Glycos... |
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Transcribed locus, moderately similar to NP_200962.2 L-asparaginase, putativ... |
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L-asparaginase, putative / L-asparagine amidohydrolase, putative |
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Aspartylglucosaminidase |
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Aspartylglucosaminidase |
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Transcribed locus, strongly similar to NP_974974.1 L-asparaginase, putative ... |
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R04B3.2 |
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Aspartylglucosaminidase |
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Aspartylglucosaminidase |
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Transcribed locus, strongly similar to XP_694881.2 PREDICTED: similar to LOC... |
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CG1827 |
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CG10474 |
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CG4372 |
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Aspartylglucosaminidase |
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Transcribed locus, weakly similar to XP_360803.2 hypothetical protein MGG_03... |
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Aspartylglucosaminidase |
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Transcribed locus, moderately similar to NP_001053482.1 Os04g0549300 [Oryza ... |
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Transcribed locus, weakly similar to NP_001026811.1 aspartylglucosaminidase ... |
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Testis cDNA, clone: QtsA-18326, similar to human aspartylglucosaminidase (AG... |
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Aspartylglucosaminidase |
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Aspartylglucosaminidase |
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Transcribed locus, moderately similar to NP_001006445.1 aspartylglucosaminid... |
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Os04g0549300 |
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Transcribed locus, moderately similar to XP_694881.2 PREDICTED: similar to L... |
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Transcribed locus, strongly similar to NP_001068979.1 hypothetical protein L... |
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Transcribed locus, strongly similar to NP_000018.1 aspartylglucosaminidase p... |
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Transcribed locus, moderately similar to XP_798176.2 PREDICTED: similar to L... |
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Transcribed locus, moderately similar to NP_200962.2 L-asparaginase, putativ... |
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Transcribed locus, moderately similar to NP_200962.2 asparaginase [Arabidops... |
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Aspartylglucosaminidase |
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Transcribed locus, moderately similar to NP_001006445.1 aspartylglucosaminid... |
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Transcribed locus, weakly similar to NP_001006445.1 aspartylglucosaminidase ... |
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Transcribed locus, weakly similar to NP_200962.2 asparaginase [Arabidopsis t... |
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Transcribed locus, moderately similar to NP_000018.1 aspartylglucosaminidase... |
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Transcribed locus, strongly similar to NP_001026811.1 aspartylglucosaminidas... |
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Similar to CG1827-PB, isoform B |
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Transcribed locus, moderately similar to NP_200962.2 asparaginase [Arabidops... |
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Transcribed locus, strongly similar to NP_001088900.1 hypothetical protein L... |
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Transcribed locus, strongly similar to NP_001088900.1 hypothetical protein L... |
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Transcribed locus, moderately similar to NP_001053482.1 Os04g0549300 [Oryza ... |
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