Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.
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Proteins
Proteins used in sequence comparisons and their conserved domain architectures.
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ADSL, Homo sapiens
adenylosuccinate lyase |
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NP_000017.1
484 aa |
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ADSL, Canis lupus familiaris
adenylosuccinate lyase |
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XP_531727.2
490 aa |
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ADSL, Bos taurus
adenylosuccinate lyase |
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NP_001095847.1
490 aa |
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Adsl, Mus musculus
adenylosuccinate lyase |
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NP_033764.2
484 aa |
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Adsl, Rattus norvegicus
adenylosuccinate lyase |
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XP_235496.3
484 aa |
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ADSL, Gallus gallus
adenylosuccinate lyase |
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NP_990860.1
459 aa |
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adsl, Danio rerio
adenylosuccinate lyase |
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NP_956193.1
482 aa |
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CG3590, Drosophila melanogaster
CG3590 |
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NP_650586.2
481 aa |
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AgaP_AGAP002378, Anopheles gambiae
AGAP002378-PA |
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XP_312577.3
483 aa |
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ade8, Schizosaccharomyces pombe
adenylosuccinate lyase Ade8 |
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NP_596735.1
482 aa |
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ADE13, Saccharomyces cerevisiae
Ade13p |
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NP_013463.1
482 aa |
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KLLA0B13189g, Kluyveromyces lactis
hypothetical protein |
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XP_452119.1
482 aa |
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AGOS_ABL006C, Eremothecium gossypii
ABL006Cp |
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NP_982941.1
482 aa |
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MGG_03645, Magnaporthe grisea
hypothetical protein |
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XP_361102.2
485 aa |
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NCU06187.1, Neurospora crassa
hypothetical protein |
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XP_326042.1
482 aa |
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Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.
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Homo sapiens |
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Adenylosuccinase deficiency. |
PubMed
Articles associated with genes and sequences of this entry plus additional related articles.
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Ariyananda Lde Z, et al.Biochemical and biophysical analysis of five disease-associated human adenylosuccinate lyase mutants. Biochemistry 48, 5291-302(2009). |
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Jurecka A, et al.Clinical, biochemical and molecular findings in seven Polish patients with adenylosuccinate lyase deficiency. Mol Genet Metab 94, 435-42(2008). |
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Mouchegh K, et al.Lethal fetal and early neonatal presentation of adenylosuccinate lyase deficiency: observation of 6 patients in 4 families. J Pediatr 150, 57-61.e2(2007). |
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Lee P & Colman RF.Expression, purification, and characterization of stable, recombinant human adenylosuccinate lyase. Protein Expr Purif 51, 227-34(2007). |
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Marinaki AM, et al.Adenylosuccinate lyase deficiency--first British case. Nucleosides Nucleotides Nucleic Acids 23, 1231-3(2004). |
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Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
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Lyase_I_like (cl00013) Lyase class I_like. Lyase class I_like superfamily of enzymes that catalyze beta-elimination reactions and are active as homotetramers. The four active sites of the homotetrameric enzyme are each formed by residues from three different subunits. This... |
Related Homology Resources
Links to curated and computed homology information found in other databases.
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Orthology group for M.musculus Adsl includes H.sapiens ADSL and R.norvegicus Adsl. |
UniGene
Links to groups of transcribed sequences established by tblastn searching of UniGene.
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Transcribed locus, weakly similar to NP_000017.1 adenylosuccinate lyase isof... |
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Transcribed locus, strongly similar to XP_312577.3 ENSANGP00000014908 [Anoph... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.2 ENSANGP00000014908 [Anoph... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.2 ENSANGP00000014908 [Anoph... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Transcribed locus, strongly similar to XP_312577.3 AGAP002378-PA [Anopheles ... |
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Similar to CG3590-PA |
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Transcribed locus, moderately similar to NP_650586.2 CG3590 CG3590-PA [Droso... |
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Adenylosuccinate lyase |
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R06C7.5a |
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Adenylosuccinate lyase |
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Transcribed locus, moderately similar to NP_000017.1 adenylosuccinate lyase ... |
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Transcribed locus, weakly similar to NP_000017.1 adenylosuccinate lyase [Hom... |
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Adenylosuccinate lyase |
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Similar to Adenylosuccinate lyase |
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CG3590 |
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Transcribed locus, strongly similar to NP_000017.1 adenylosuccinate lyase is... |
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Transcribed locus, strongly similar to NP_956193.1 adenylosuccinate lyase [D... |
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Adenylosuccinate lyase |
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Clone CGX91-H08 mRNA sequence |
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Transcribed locus, moderately similar to NP_956193.1 adenylosuccinate lyase ... |
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Transcribed locus, weakly similar to XP_326042.1 hypothetical protein [Neuro... |
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Adenylosuccinate lyase |
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Transcribed locus, moderately similar to NP_000017.1 adenylosuccinate lyase ... |
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Adsl mRNA for adenylosuccinate lyase |
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Similar to adenylosuccinate lyase |
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Transcribed locus, weakly similar to NP_000017.1 adenylosuccinate lyase [Hom... |
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Adenylosuccinate lyase |
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Transcribed locus, strongly similar to NP_033764.2 adenylosuccinate lyase [M... |
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Transcribed locus, strongly similar to NP_956193.1 adenylosuccinate lyase [D... |
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Transcribed locus, moderately similar to NP_000017.1 adenylosuccinate lyase ... |
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Transcribed locus, strongly similar to NP_956193.1 adenylosuccinate lyase [D... |
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Transcribed locus, strongly similar to NP_000017.1 adenylosuccinate lyase [H... |
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Transcribed locus, weakly similar to NP_000017.1 adenylosuccinate lyase isof... |
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Transcribed locus, strongly similar to NP_956193.1 adenylosuccinate lyase [D... |
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Adenylosuccinate lyase |
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Transcribed locus, strongly similar to NP_956193.1 adenylosuccinate lyase [D... |
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Clone SJAABCD05 adenylosuccinate lyase (ADL) |
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Adenylosuccinate lyase (ASL) |
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Similar to adenysuccinate lyase |
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Transcribed locus, strongly similar to NP_000017.1 adenylosuccinate lyase is... |
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Similar to CG3590-PA |
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Adenylosuccinate lyase |
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Adenylosuccinate lyase |
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