Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.
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Proteins
Proteins used in sequence comparisons and their conserved domain architectures.
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ABCA1, Homo sapiens
ATP-binding cassette, sub-family A (ABC1), member 1 |
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NP_005493.2
2261 aa |
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ABCA1, Pan troglodytes
ATP-binding cassette, sub-family A (ABC1), member 1 |
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XP_001138040.1
2261 aa |
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ABCA1, Canis lupus familiaris
ATP-binding cassette, sub-family A (ABC1), member 1 |
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XP_538773.2
2261 aa |
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ABCA1, Bos taurus
ATP-binding cassette, sub-family A (ABC1), member 1 |
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NP_001019864.1
2261 aa |
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Abca1, Mus musculus
ATP-binding cassette, sub-family A (ABC1), member 1 |
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NP_038482.3
2261 aa |
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Abca1, Rattus norvegicus
ATP-binding cassette, sub-family A (ABC1), member 1 |
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NP_835196.1
2201 aa |
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ABCA1, Gallus gallus
ATP-binding cassette, sub-family A (ABC1), member 1 |
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NP_989476.1
2260 aa |
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abca1a, Danio rerio
ATP-binding cassette, sub-family A (ABC1), member 1A |
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XP_687304.3
2274 aa |
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AT2G41700, Arabidopsis thaliana
ATPase, coupled to transmembrane movement of substances / amino acid transmembrane transporter |
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NP_850354.2
1882 aa |
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Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.
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Homo sapiens |
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Coronary artery disease in familial hypercholesterolemia, protection against. |
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Tangier disease. |
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HDL deficiency, familial. |
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Mus musculus |
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Renal/urinary system phenotype. |
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Muscle phenotype. |
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Liver/biliary system phenotype. |
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Lethality-postnatal. |
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Lethality-prenatal/perinatal. |
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Homeostasis/metabolism phenotype. |
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Growth/size phenotype. |
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Endocrine/exocrine gland phenotype. |
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Embryogenesis phenotype. |
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Digestive/alimentary phenotype. |
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Cellular phenotype. |
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Cardiovascular system phenotype. The observable morphological and physiological characteristics of the mammalian heart, blood vessels, or circulatory system that are manifested through development and lifespan. |
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Immune system phenotype. |
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Respiratory system phenotype. |
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Reproductive system phenotype. |
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Hematopoietic system phenotype. |
PubMed
Articles associated with genes and sequences of this entry plus additional related articles.
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Hu S, et al.Novel rare alleles of ABCA1 are exclusively associated with extreme high-density lipoprotein-cholesterol levels among the Han Chinese. Clin Chem Lab Med 47, 1239-45(2009). |
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Li J, et al.Effect of R219K polymorphism of the ABCA1 gene on the lipid-lowering effect of pravastatin in Chinese patients with coronary heart disease. Clin Exp Pharmacol Physiol 36, 567-70(2009). |
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Zuo Y, et al.Renal dysfunction potentiates foam cell formation by repressing ABCA1. Arterioscler Thromb Vasc Biol 29, 1277-82(2009). |
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Pradel LC, et al.ATP-binding cassette transporter hallmarks tissue macrophages and modulates cytokine-triggered polarization programs. Eur J Immunol 39, 2270-80(2009). |
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Reynolds CA, et al.A survey of ABCA1 sequence variation confirms association with dementia. Hum Mutat 30, 1348-54(2009). |
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Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
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Related Homology Resources
Links to curated and computed homology information found in other databases.
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Orthology group for M.musculus Abca1 includes H.sapiens ABCA1 and R.norvegicus Abca1. |
UniGene
Links to groups of transcribed sequences established by tblastn searching of UniGene.
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Similar to ATP-binding cassette, sub-family A (ABC1), member 1 |
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Transcribed locus, weakly similar to XP_001112698.1 PREDICTED: similar to AT... |
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Transcribed locus, weakly similar to NP_001031526.1 unknown protein [Arabido... |
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AT2G41700 hypothetical protein |
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ATP-binding cassette, sub-family A (ABC1), member 1 |
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Similar to ATP-binding cassette sub-family A member 1 |
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ATP-binding cassette, sub-family A (ABC1), member 1 |
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Transcribed locus, moderately similar to NP_001031526.1 unknown protein [Ara... |
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Similar to ATP-binding cassette transporter 1 |
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ATP-binding cassette, sub-family A (ABC1), member 1A |
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Similar to ATP-binding cassette transporter 1 |
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ATP-binding cassette, sub-family A (ABC1), member 1 |
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Similar to ATP-binding cassette transporter 1 |
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Transcribed locus, weakly similar to NP_850354.2 ATPase, coupled to transmem... |
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Transcribed locus, weakly similar to NP_850354.2 ATPase, coupled to transmem... |
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Transcribed locus, weakly similar to XP_001481309.1 PREDICTED: similar to AT... |
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ATP-binding cassette, sub-family A (ABC1), member 1 |
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Transcribed locus, weakly similar to NP_850354.2 ATPase, coupled to transmem... |
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ATP-binding cassette, sub-family A (ABC1), member 1 |
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ATP-binding cassette, sub-family A (ABC1), member 1 |
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Transcribed locus, moderately similar to XP_001481309.1 PREDICTED: similar t... |
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Transcribed locus, strongly similar to NP_835196.1 ATP-binding cassette, sub... |
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Transcribed locus, strongly similar to XP_001184310.1 PREDICTED: similar to ... |
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Transcribed locus, strongly similar to XP_001184310.1 PREDICTED: similar to ... |
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Transcribed locus, moderately similar to XP_001112698.1 PREDICTED: similar t... |
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Transcribed locus, weakly similar to NP_001031526.1 unknown protein [Arabido... |
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Transcribed locus, moderately similar to NP_001031526.1 unknown protein [Ara... |
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Transcribed locus, moderately similar to NP_001031526.1 unknown protein [Ara... |
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ATP-binding cassette, sub-family A (ABC1), member 1 |
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Transcribed locus, moderately similar to XP_001112698.1 PREDICTED: similar t... |
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Transcribed locus, weakly similar to NP_850354.2 ATPase, coupled to transmem... |
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ATP-binding cassette transporter subfamily A |
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Transcribed locus, strongly similar to XP_001112698.1 PREDICTED: similar to ... |
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Transcribed locus, weakly similar to NP_001031526.1 unknown protein [Arabido... |
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Transcribed locus, strongly similar to XP_001112698.1 PREDICTED: similar to ... |
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