Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.
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Proteins
Proteins used in sequence comparisons and their conserved domain architectures.
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PPARGC1A, Homo sapiens
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
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NP_037393.1
798 aa |
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PPARGC1A, Canis lupus familiaris
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
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XP_851741.1
796 aa |
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PPARGC1A, Bos taurus
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
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NP_808814.1
796 aa |
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Ppargc1a, Mus musculus
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha |
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NP_032930.1
797 aa |
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Ppargc1a, Rattus norvegicus
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
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NP_112637.1
796 aa |
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PPARGC1A, Gallus gallus
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
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NP_001006457.1
795 aa |
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ppargc1al, Danio rerio
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha like |
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XP_001922959.1
873 aa |
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Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.
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Homo sapiens |
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Lipodystrophy, familial partial, with decreased subcutaneous fat of face and neck. |
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Mus musculus |
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Nervous system phenotype. |
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Muscle phenotype. |
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Liver/biliary system phenotype. |
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Life span-post-weaning/aging. |
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Lethality-postnatal. |
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Lethality-prenatal/perinatal. |
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Adipose tissue phenotype. The observable morphological and physiological characteristics of mammalian fat tissue that are manifested through development and lifespan. |
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Homeostasis/metabolism phenotype. |
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Hearing/vestibular/ear phenotype. |
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Growth/size phenotype. |
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Cellular phenotype. |
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Cardiovascular system phenotype. The observable morphological and physiological characteristics of the mammalian heart, blood vessels, or circulatory system that are manifested through development and lifespan. |
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Behavior/neurological phenotype. The observable actions or reactions of mammalian organisms that are manifested through development and lifespan. |
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Respiratory system phenotype. |
PubMed
Articles associated with genes and sequences of this entry plus additional related articles.
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Qu A, et al.PGC-1alpha attenuates neointimal formation via inhibition of vascular smooth muscle cell migration in the injured rat carotid artery. Am J Physiol Cell Physiol 297, C645-53(2009). |
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Kim JW, et al.Suppression of peroxisome proliferator-activated receptor gamma-coactivator-1alpha normalizes the glucolipotoxicity-induced decreased BETA2/NeuroD gene transcription and improved glucose tolerance in diabetic rats. Endocrinology 150, 4074-83(2009). |
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Chaturvedi RK, et al.Impaired PGC-1alpha function in muscle in Huntington's disease. Hum Mol Genet 18, 3048-65(2009). |
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Adhihetty PJ, et al.The role of PGC-1alpha on mitochondrial function and apoptotic susceptibility in muscle. Am J Physiol Cell Physiol 297, C217-25(2009). |
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Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
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RRM (cl02586) RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA... |
Related Homology Resources
Links to curated and computed homology information found in other databases.
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Orthology group for M.musculus Ppargc1a includes H.sapiens PPARGC1A and R.norvegicus Ppargc1a. |
UniGene
Links to groups of transcribed sequences established by tblastn searching of UniGene.
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Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
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Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
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Expressed sequence DQ017637 |
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Expressed sequence DQ017637 |
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Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
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Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
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Testis cDNA, clone: QtsA-20042, similar to human peroxisome proliferative ac... |
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Peroxisome proliferative activated receptor, gamma, coactivator 1 alpha |
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Peroxisome proliferative activated receptor gamma coactivator 1 |
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Peroxisome proliferative activated receptor, gamma, coactivator 1 alpha |
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Peroxisome proliferator activated receptor,gamma,coactivator 1 |
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Peroxisome proliferator activated receptor gamma coactivator 1 alpha |
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