Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.
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Proteins
Proteins used in sequence comparisons and their conserved domain architectures.
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CASP4, Homo sapiens
caspase 4, apoptosis-related cysteine peptidase |
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NP_001216.1
377 aa |
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CASP4, Pan troglodytes
caspase 4, apoptosis-related cysteine peptidase |
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XP_508729.2
377 aa |
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CASP4, Canis lupus familiaris
caspase 4, apoptosis-related cysteine peptidase |
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NP_001003125.1
404 aa |
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CASP4, Bos taurus
caspase 4, apoptosis-related cysteine peptidase |
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NP_788811.1
377 aa |
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Casp4, Mus musculus
caspase 4, apoptosis-related cysteine peptidase |
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NP_031635.1
373 aa |
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Casp4, Rattus norvegicus
caspase 4, apoptosis-related cysteine peptidase |
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NP_446188.2
373 aa |
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Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.
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Mus musculus |
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Homeostasis/metabolism phenotype. |
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Immune system phenotype. |
PubMed
Articles associated with genes and sequences of this entry plus additional related articles.
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Lee JM, et al.The involvement of caspase-11 in TPEN-induced apoptosis. FEBS Lett 582, 1871-6(2008). |
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Oda T, et al.Distinct mechanism of cell death is responsible for tunicamycin-induced ER stress in SK-N-SH and SH-SY5Y cells. Neurosci Res 60, 29-39(2008). |
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Oizumi H, et al.Alteration in the differentiation-related molecular expression in the subventricular zone in a mouse model of Parkinson's disease. Neurosci Res 60, 15-21(2008). |
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Furuya T, et al.Caspase-11 mediates inflammatory dopaminergic cell death in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. J Neurosci 24, 1865-72(2004). |
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Kang SJ, et al.Dissociation between neurodegeneration and caspase-11-mediated activation of caspase-1 and caspase-3 in a mouse model of amyotrophic lateral sclerosis. J Neurosci 23, 5455-60(2003). |
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Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
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CASc (cl00042) Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide... |
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Related Homology Resources
Links to curated and computed homology information found in other databases.
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Orthology group for M.musculus Casp4 includes H.sapiens CASP4 and R.norvegicus Casp4. |
UniGene
Links to groups of transcribed sequences established by tblastn searching of UniGene.
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Caspase 4, apoptosis-related cysteine peptidase |
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Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, conver... |
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Caspase 4, apoptosis-related cysteine peptidase |
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Similar to evolutionarily related interleukin-1beta converting enzyme |
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Caspase-1 |
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Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, conver... |
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Caspase 4, apoptosis-related cysteine peptidase |
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Caspase 5, apoptosis-related cysteine peptidase |
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Transcribed locus, strongly similar to NP_001216.1 caspase 4 isoform alpha p... |
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Caspase 4 |
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Caspase 1 |
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Caspase 4, apoptosis-related cysteine peptidase |
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Caspase 11 |
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Transcribed locus, strongly similar to NP_788811.1 caspase 4 [Bos taurus] |
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Transcribed locus, strongly similar to NP_150649.1 caspase 4 isoform gamma p... |
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Caspase 4, apoptosis-related cysteine peptidase |
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Transcribed locus, moderately similar to NP_001216.1 caspase 4 isoform alpha... |
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Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, conver... |
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Transcribed locus, moderately similar to XP_001381571.1 PREDICTED: similar t... |
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