1: HomoloGene:8134. Gene conserved in Amniota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   FBXO4,  Homo sapiens
F-box protein 4
    NP_036308.1
387 aa
Domain Image
   FBXO4,  Pan troglodytes
F-box protein 4
    XP_001137206.1
388 aa
Domain Image
   FBXO4,  Canis lupus familiaris
F-box protein 4
    XP_546338.1
387 aa
Domain Image
   FBXO4,  Bos taurus
F-box protein 4
    NP_001029789.1
387 aa
Domain Image
   FBXO4,  Bos taurus
F-box protein 4
    XP_001787155.1
387 aa
Domain Image
   Fbxo4,  Mus musculus
F-box protein 4
    NP_598860.1
385 aa
Domain Image
   Fbxo4,  Rattus norvegicus
F-box protein 4
    XP_227090.4
431 aa
   FBXO4,  Gallus gallus
F-box protein 4
    XP_429141.2
386 aa
Domain Image


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenrate Alignments




PubMed
Articles associated with genes and sequences of this entry plus additional related articles.

 
Barbash O, et al.
Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer. Cancer Cell 14, 68-78(2008).
 
Lin DI, et al.
Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex. Mol Cell 24, 355-66(2006).
 
Lee TH, et al.
The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance. J Biol Chem 281, 759-68(2006).
 
Liu Y, et al.
The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2. Mol Cell Biol 26, 3114-23(2006).
 
Chiaur DS, et al.
Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. Cytogenet Cell Genet 88, 255-8(2000).
 

 


Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.

 
F-box (cl02535)
  F-box domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.

 
Orthology group for M.musculus Fbxo4 includes H.sapiens FBXO4 and R.norvegicus Fbxo4.



UniGene
Links to groups of transcribed sequences established by tblastn searching of UniGene.

 
F-box protein 4
 
F-box protein 4
 
F-box protein 4
 
Similar to F-box protein 4
 
F-box protein 4
 
F-box protein 4
 
Similar to F-box only protein 4 isoform 2
 
F-box protein 4
 
F-box protein 4
 
Transcribed locus, strongly similar to XP_001252002.1 PREDICTED: similar to ...
 
Hypothetical protein LOC548694
 
CDNA clone MGC:179864 IMAGE:5073290