1: HomoloGene:461. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TPO,  Homo sapiens
thyroid peroxidase
    NP_000538.3
933 aa
Domain ImageDomain ImageDomain Image
   TPO,  Canis lupus familiaris
thyroid peroxidase
    NP_001003009.1
933 aa
Domain ImageDomain ImageDomain Image
   TPO,  Bos taurus
thyroid peroxidase
    XP_603356.4
1107 aa
Domain ImageDomain ImageDomain Image
   Tpo,  Mus musculus
thyroid peroxidase
    NP_033443.1
914 aa
Domain ImageDomain ImageDomain Image
   Tpo,  Rattus norvegicus
thyroid peroxidase
    NP_062226.1
914 aa
Domain ImageDomain ImageDomain Image
   TPO,  Gallus gallus
thyroid peroxidase
    XP_001235673.1
793 aa
Domain ImageDomain ImageDomain Image
   LOC569363,  Danio rerio
similar to thyroid peroxidase
    XP_697836.3
679 aa
Domain Image


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenrate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.


  Homo sapiens
 
Thyroid hormone organification defect IIA.
 
Total iodide organification defect.
 
Goiter, congenital.
 
Hyperthyroidism, congenital.
 
Mus musculus
 
Life span-post-weaning/aging.
 
Homeostasis/metabolism phenotype.
 
Growth/size phenotype.
 
Endocrine/exocrine gland phenotype.
 
Immune system phenotype.
 
Hematopoietic system phenotype.



PubMed
Articles associated with genes and sequences of this entry plus additional related articles.

 
Mavragani CP, et al.
Increased prevalence of antibodies to thyroid peroxidase in dry eyes and mouth syndrome or sicca asthenia polyalgia syndrome. J Rheumatol 36, 1626-30(2009).
 
Simm D, et al.
Two novel mutations in the human thyroid peroxidase (TPO) gene: genetics and clinical findings in four children. Acta Paediatr 98, 1057-61(2009).
 
Fuchs O, et al.
Congenital hypothyroidism caused by a novel homozygous mutation in the thyroid peroxidase gene. J Pediatr Endocrinol Metab 21, 1093-7(2008).
 
Kessler J, et al.
Factors influencing the study of peroxidase-generated iodine species and implications for thyroglobulin synthesis. Thyroid 18, 769-74(2008).
 
Yang M, et al.
Thrombopoietin levels increased in patients with severe acute respiratory syndrome. Thromb Res 122, 473-7(2008).
 

 


Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.

 
An_peroxidase (pfam03098)
  Animal haem peroxidase.
 
CCP (cl00043)
  Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues...
 
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...



Related Homology Resources
Links to curated and computed homology information found in other databases.

 
Orthology group for M.musculus Tpo includes H.sapiens TPO and R.norvegicus Tpo.



UniGene
Links to groups of transcribed sequences established by tblastn searching of UniGene.

 
Thyroid peroxidase
 
Similar to thyroid peroxidase
 
Thyroid peroxidase
 
Thyroid peroxidase
 
Thyroid peroxidase
 
Thyroid peroxidase
 
Thyroid peroxidase
 
Thyroid peroxidase