Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.
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Proteins
Proteins used in sequence comparisons and their conserved domain architectures.
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THOC1, Homo sapiens
THO complex 1 |
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NP_005122.2
657 aa |
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THOC1, Pan troglodytes
THO complex 1 |
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XP_512049.2
657 aa |
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THOC1, Canis lupus familiaris
THO complex 1 |
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XP_547651.2
657 aa |
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LOC100138748, Bos taurus
similar to THO complex 1 |
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XP_001788610.1
657 aa |
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Thoc1, Mus musculus
THO complex 1 |
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NP_705780.1
657 aa |
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THOC1, Gallus gallus
THO complex 1 |
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XP_419149.2
540 aa |
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thoc1, Danio rerio
THO complex 1 |
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NP_958481.1
655 aa |
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Hpr1, Drosophila melanogaster
Hpr1 |
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NP_649594.1
701 aa |
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AgaP_AGAP004070, Anopheles gambiae
AGAP004070-PA |
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XP_309625.3
682 aa |
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thoc-1, Caenorhabditis elegans
THO Complex (transcription factor/nuclear export) subunit |
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NP_493796.2
665 aa |
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Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.
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Mus musculus |
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Lethality-prenatal/perinatal. |
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Growth/size phenotype. |
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Embryogenesis phenotype. |
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Cellular phenotype. |
PubMed
Articles associated with genes and sequences of this entry plus additional related articles.
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Wang X, et al.Thoc1 deficiency compromises gene expression necessary for normal testis development in the mouse. Mol Cell Biol 29, 2794-803(2009). |
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Yang J, et al.Relationships of hHpr1/p84/Thoc1 expression to clinicopathologic characteristics and prognosis in non-small cell lung cancer. Ann Clin Lab Sci 38, 105-12(2008). |
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Garner E, et al.Cells with defective p53-p21-pRb pathway are susceptible to apoptosis induced by p84N5 via caspase-6. Cancer Res 67, 7631-7(2007). |
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Li Y, et al.Cancer cells and normal cells differ in their requirements for Thoc1. Cancer Res 67, 6657-64(2007). |
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Wang X, et al.Thoc1/Hpr1/p84 is essential for early embryonic development in the mouse. Mol Cell Biol 26, 4362-7(2006). |
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Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
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Related Homology Resources
Links to curated and computed homology information found in other databases.
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Orthology group for M.musculus Thoc1 includes H.sapiens THOC1. |
UniGene
Links to groups of transcribed sequences established by tblastn searching of UniGene.
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Strain Liverpool chromosome 1 |
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Similar to Hpr1 CG2031-PA |
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CDNA clone IMAGE:8233852 |
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Transcribed locus, weakly similar to NP_705780.1 THO complex 1 [Mus musculus... |
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T02H6.2 |
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THO complex 1 |
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THO complex 1 |
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Hpr1 |
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THO complex 1 |
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Clone CFW236-F03 mRNA sequence |
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THO complex 1 |
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Transcribed locus, weakly similar to XP_001521474.1 PREDICTED: hypothetical ... |
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Brain cDNA clone: QmoA-10276, similar to human THO complex 1 (THOC1), mRNA, ... |
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THO complex 1 |
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Transcribed locus, weakly similar to XP_001508566.1 PREDICTED: hypothetical ... |
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THO complex 1 |
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Transcribed locus, moderately similar to NP_958481.1 THO complex 1 [Danio re... |
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Transcribed locus, moderately similar to NP_958481.1 THO complex 1 [Danio re... |
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Transcribed locus, strongly similar to NP_705780.1 THO complex 1 [Mus muscul... |
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Transcribed locus, strongly similar to NP_705780.1 THO complex 1 [Mus muscul... |
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Transcribed locus, strongly similar to NP_958481.1 THO complex 1 [Danio reri... |
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Transcribed locus, moderately similar to NP_705780.1 THO complex 1 [Mus musc... |
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THO complex 1 |
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Transcribed locus, moderately similar to NP_958481.1 THO complex 1 [Danio re... |
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Transcribed locus, strongly similar to NP_705780.1 THO complex 1 [Mus muscul... |
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Transcribed locus, strongly similar to NP_705780.1 THO complex 1 [Mus muscul... |
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THO complex 1 |
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Similar to nuclear matrix protein |
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