1: HomoloGene:2662. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CUL2,  Homo sapiens
cullin 2
    NP_003582.2
745 aa
Domain ImageDomain Image
   CUL2,  Pan troglodytes
cullin 2
    XP_507738.2
829 aa
Domain ImageDomain Image
   CUL2,  Canis lupus familiaris
cullin 2
    XP_535140.2
745 aa
Domain ImageDomain Image
   CUL2,  Bos taurus
cullin 2
    NP_001070377.1
745 aa
Domain ImageDomain Image
   Cul2,  Mus musculus
cullin 2
    NP_083678.1
706 aa
Domain ImageDomain Image
   Cul2,  Rattus norvegicus
cullin 2
    XP_341543.2
706 aa
   CUL2,  Gallus gallus
cullin 2
    NP_001026141.1
688 aa
Domain Image
   LOC572113,  Danio rerio
similar to cullin 2
    XP_700883.2
745 aa
Domain ImageDomain Image
   cul-2,  Drosophila melanogaster
cul-2, isoform A
    NP_610117.1
753 aa
Domain ImageDomain Image
   AgaP_AGAP003605,  Anopheles gambiae
AGAP003605-PA
    XP_313365.4
766 aa
Domain ImageDomain Image
   cul-2,  Caenorhabditis elegans
CULlin
    NP_499825.3
850 aa
Domain ImageDomain Image


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenrate Alignments




PubMed
Articles associated with genes and sequences of this entry plus additional related articles.

 
Johnson JL, et al.
Levels of the ubiquitin ligase substrate adaptor MEL-26 are inversely correlated with MEI-1/katanin microtubule-severing activity during both meiosis and mitosis. Dev Biol 330, 349-57(2009).
 
DeRenzo C, et al.
Exclusion of germ plasm proteins from somatic lineages by cullin-dependent degradation. Nature 424, 685-9(2003).
 
Huh K, et al.
Human papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor. J Virol 81, 9737-47(2007).
 
Liu J, et al.
CUL-2 and ZYG-11 promote meiotic anaphase II and the proper placement of the anterior-posterior axis in C. elegans. Development 131, 3513-25(2004).
 
Sonneville R & Gönczy P.
Zyg-11 and cul-2 regulate progression through meiosis II and polarity establishment in C. elegans. Development 131, 3527-43(2004).
 

 


Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.

 
Cullin_Nedd8 (pfam10557)
  Cullin protein neddylation domain.
 



Related Homology Resources
Links to curated and computed homology information found in other databases.

 
Orthology group for M.musculus Cul2 includes H.sapiens CUL2 and R.norvegicus Cul2.



UniGene
Links to groups of transcribed sequences established by tblastn searching of UniGene.

 
Strain Liverpool
 
Transcribed locus, strongly similar to XP_313365.4 AGAP003605-PA [Anopheles ...
 
Transcribed locus, strongly similar to XP_313365.4 AGAP003605-PA [Anopheles ...
 
Similar to cul-2 CG1512-PB, isoform B
 
Cullin 2
 
CULlin
 
Cullin 2
 
Similar to hCG2040100
 
Cul-2
 
Cullin 2
 
Transcribed locus, strongly similar to NP_001026141.1 cullin 2 [Gallus gallu...
 
Transcribed locus, moderately similar to NP_001026141.1 cullin 2 [Gallus gal...
 
Cullin 2
 
Transcribed locus, strongly similar to NP_001026141.1 cullin 2 [Gallus gallu...
 
Cullin 2
 
Similar to cullin 2
 
Cullin 2
 
Transcribed locus, strongly similar to NP_003582.2 cullin 2 [Homo sapiens]
 
Transcribed locus, strongly similar to NP_001026141.1 cullin 2 [Gallus gallu...
 
Transcribed locus, strongly similar to NP_003582.2 cullin 2 [Homo sapiens]
 
Transcribed locus, strongly similar to XP_700883.2 PREDICTED: similar to hCG...
 
Cullin 2
 
Transcribed locus, strongly similar to NP_003582.2 cullin 2 [Homo sapiens]
 
Hypothetical LOC593708
 
Transcribed locus, strongly similar to NP_001026141.1 cullin 2 [Gallus gallu...
 
Similar to CG1512-PB, isoform B
 
Transcribed locus, strongly similar to NP_001026141.1 cullin 2 [Gallus gallu...
 
Finished cDNA, clone TGas016g10
 
Transcribed locus, strongly similar to NP_001026141.1 cullin 2 [Gallus gallu...
 
Hypothetical protein MGC69167