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    TERF2 telomeric repeat binding factor 2 [ Equus caballus (horse) ]

    Gene ID: 100067122, updated on 8-Mar-2024

    Summary

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    Official Symbol
    TERF2provided by VGNC
    Official Full Name
    telomeric repeat binding factor 2provided by VGNC
    Primary source
    VGNC:VGNC:24004
    See related
    Ensembl:ENSECAG00000024534
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    103 current EquCab3.0 (GCF_002863925.1) 3 NC_009146.3 (20114953..20138591, complement)
    102 previous assembly EquCab2.0 (GCF_000002305.2) 3 NC_009146.2 (19421164..19445283, complement)

    Chromosome 3 - NC_009146.3Genomic Context describing neighboring genes Neighboring gene component of oligomeric golgi complex 8 Neighboring gene nucleolar pre-rRNA processing protein NIP7 Neighboring gene transmembrane p24 trafficking protein 6 Neighboring gene uncharacterized LOC102148636 Neighboring gene cytochrome b5 type B Neighboring gene ER membrane protein complex subunit 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G-rich strand telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables double-stranded telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables telomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of telomere maintenance via recombination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of telomeric D-loop disassembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protection from non-homologous end joining at telomere IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein localization to chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of telomere maintenance via telomerase IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in telomeric D-loop disassembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in telomeric loop formation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of shelterin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    telomeric repeat-binding factor 2
    Names
    Telomeric repeat-binding factor 2-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009146.3 Reference EquCab3.0 Primary Assembly

      Range
      20114953..20138591 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023637208.1 → XP_023492976.1  telomeric repeat-binding factor 2 isoform X4

      Conserved Domains (3) summary
      cd11660
      Location:412 → 460
      SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
      pfam16772
      Location:240 → 280
      TERF2_RBM; Telomeric repeat-binding factor 2 Rap1-binding motif
      cl02779
      Location:87 → 202
      TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

    2. XM_023637207.1 → XP_023492975.1  telomeric repeat-binding factor 2 isoform X3

      Conserved Domains (3) summary
      cd11660
      Location:441 → 489
      SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
      pfam16772
      Location:269 → 309
      TERF2_RBM; Telomeric repeat-binding factor 2 Rap1-binding motif
      cl02779
      Location:87 → 237
      TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

    3. XM_023637205.1 → XP_023492973.1  telomeric repeat-binding factor 2 isoform X2

      Conserved Domains (3) summary
      cd11660
      Location:489 → 537
      SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
      cd00280
      Location:87 → 286
      TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...
      pfam16772
      Location:318 → 358
      TERF2_RBM; Telomeric repeat-binding factor 2 Rap1-binding motif

    4. XM_005614984.2 → XP_005615041.2  telomeric repeat-binding factor 2 isoform X1

      UniProtKB/TrEMBL
      F6RQ75
      Related
      ENSECAP00000022045.2, ENSECAT00000026430.4
      Conserved Domains (3) summary
      cd11660
      Location:490 → 538
      SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
      cd00280
      Location:87 → 286
      TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...
      pfam16772
      Location:318 → 358
      TERF2_RBM; Telomeric repeat-binding factor 2 Rap1-binding motif
    Nucleotide Protein
    Heading Accession and Version

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