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    CDX2 caudal type homeobox 2 [ Bos taurus (cattle) ]

    Gene ID: 618679, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CDX2provided by VGNC
    Official Full Name
    caudal type homeobox 2provided by VGNC
    Primary source
    VGNC:VGNC:106684
    See related
    BGD:BT10880; Ensembl:ENSBTAG00000001819
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CDX-2
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 12 NC_037339.1 (32083554..32089291)

    Chromosome 12 - NC_037339.1Genomic Context describing neighboring genes Neighboring gene fms related receptor tyrosine kinase 3 Neighboring gene microRNA mir-2285o-2 Neighboring gene ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase Neighboring gene pancreatic and duodenal homeobox 1 Neighboring gene transfer RNA cysteine (anticodon GCA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037339.1 Chromosome 12 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Follistatin supplementation induces changes in CDX2 CpG methylation and improves in vitro development of bovine SCNT preimplantation embryos. Ashry M, et al. Reprod Biol Endocrinol, 2021 Sep 13. PMID 34517901, Free PMC Article
    2. Follistatin treatment modifies DNA methylation of the CDX2 gene in bovine preimplantation embryos. Ashry M, et al. Mol Reprod Dev, 2020 Sep. PMID 32776625, Free PMC Article
    3. Functional characterization of CDX2 during bovine preimplantation development in vitro. Goissis MD, et al. Mol Reprod Dev, 2014 Oct. PMID 25251051
    4. Lysophosphatidic Acid Accelerates Bovine In Vitro-Produced Blastocyst Formation through the Hippo/YAP Pathway. Yu B, et al. Int J Mol Sci, 2021 May 31. PMID 34072880, Free PMC Article
    5. Wnt3a Activates the WNT-YAP/TAZ Pathway to Sustain CDX2 Expression in Bovine Trophoblast Stem Cells. Wang C, et al. DNA Cell Biol, 2019 May. PMID 30896984

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Follistatin supplementation induces changes in CDX2 CpG methylation and improves in vitro development of bovine SCNT preimplantation embryos.
      Title: Follistatin supplementation induces changes in CDX2 CpG methylation and improves in vitro development of bovine SCNT preimplantation embryos.
    2. Follistatin treatment modifies DNA methylation of the CDX2 gene in bovine preimplantation embryos.
      Title: Follistatin treatment modifies DNA methylation of the CDX2 gene in bovine preimplantation embryos.
    3. Lysophosphatidic Acid Accelerates Bovine In Vitro-Produced Blastocyst Formation through the Hippo/YAP Pathway.
      Title: Lysophosphatidic Acid Accelerates Bovine In Vitro-Produced Blastocyst Formation through the Hippo/YAP Pathway.
    4. Removal of Wnt3a from the culture medium resulted in downregulation (p < 0.05) of NANOG, OCT4, CDX2, and Action: Trophoblast stem cell(TSC) marker genes, and upregulation of TSC differentiation markers, including MASH2, GCM1, and PAG
      Title: Wnt3a Activates the WNT-YAP/TAZ Pathway to Sustain CDX2 Expression in Bovine Trophoblast Stem Cells.
    5. results thus indicate that CDX2 is not required for TE formation during bovine development; nevertheless, it is necessary for maintaining TE integrity.
      Title: Functional characterization of CDX2 during bovine preimplantation development in vitro.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in anterior/posterior axis specification IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in embryo development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homeobox protein CDX-2
    Names
    caudal type homeobox transcription factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206299.1 → NP_001193228.1  homeobox protein CDX-2

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000012
      UniProtKB/TrEMBL
      F1MJX0
      Related
      ENSBTAP00000044587.4, ENSBTAT00000047376.4
      Conserved Domains (2) summary
      pfam00046
      Location:190 → 242
      Homeobox; Homeobox domain
      pfam04731
      Location:13 → 171
      Caudal_act; Caudal like protein activation region

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037339.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      32083554..32089291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024999988.2 → XP_024855756.1  homeobox protein CDX-2 isoform X1

      Conserved Domains (2) summary
      pfam00046
      Location:190 → 228
      Homeobox; Homeobox domain
      pfam04731
      Location:13 → 171
      Caudal_act; Caudal like protein activation region
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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