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Znfx1 zinc finger, NFX1-type containing 1 [ Mus musculus (house mouse) ]

Gene ID: 98999, updated on 5-Mar-2024

Summary

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Official Symbol
Znfx1provided by MGI
Official Full Name
zinc finger, NFX1-type containing 1provided by MGI
Primary source
MGI:MGI:2138982
See related
Ensembl:ENSMUSG00000039501 AllianceGenome:MGI:2138982
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Astx3
Summary
Predicted to enable RNA binding activity. Predicted to be involved in heterochromatin assembly by small RNA. Predicted to be located in nucleus. Predicted to be part of nuclear RNA-directed RNA polymerase complex. Orthologous to human ZNFX1 (zinc finger NFX1-type containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 12.8), genital fat pad adult (RPKM 12.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Znfx1 in Genome Data Viewer
Location:
2 H3; 2 87.22 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (166877713..166904926, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (167035790..167063015, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene GLE1 RNA export mediator pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2656 Neighboring gene DEAD box helicase 27 Neighboring gene STARR-positive B cell enhancer ABC_E6022 Neighboring gene predicted gene, 25878 Neighboring gene zinc finger, NFX1-type containing 1, antisense RNA 1 Neighboring gene predicted gene, 23201

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZNFX1 antisense RNA1 promotes antiviral innate immune responses via modulating ZNFX1 function. Jia X, et al. J Med Virol, 2023 Mar. PMID 36892175
  2. Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS. Wang Y, et al. Nat Cell Biol, 2019 Nov. PMID 31685995
  3. Intragenic enhancers act as alternative promoters. Kowalczyk MS, et al. Mol Cell, 2012 Feb 24. PMID 22264824
  4. Genomic variants in an inbred mouse model predict mania-like behaviors. Saul MC, et al. PLoS One, 2018. PMID 29768498, Free PMC Article
  5. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNFX1 promotes AMPK-mediated autophagy against Mycobacterium tuberculosis by stabilizing Prkaa2 mRNA.
    Title: ZNFX1 promotes AMPK-mediated autophagy against Mycobacterium tuberculosis by stabilizing Prkaa2 mRNA.
  2. ZNFX1 antisense RNA1 promotes antiviral innate immune responses via modulating ZNFX1 function.
    Title: ZNFX1 antisense RNA1 promotes antiviral innate immune responses via modulating ZNFX1 function.
  3. Mitochondria-localized ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS.
    Title: Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in activation of innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulatory ncRNA-mediated heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear RNA-directed RNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NFX1-type zinc finger-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033196.3 → NP_001028368.2  NFX1-type zinc finger-containing protein 1 isoform a

    See identical proteins and their annotated locations for NP_001028368.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AL591711
    Consensus CDS
    CCDS38337.1
    UniProtKB/Swiss-Prot
    A2A5R3, Q3U016, Q3UD71, Q3UEZ0, Q8R151
    Related
    ENSMUSP00000049404.8, ENSMUST00000048988.14
    Conserved Domains (6) summary
    cd06008
    Location:1453 → 1497
    NF-X1-zinc-finger; Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger ...
    PRK03918
    Location:1597 → 1808
    PRK03918; DNA double-strand break repair ATPase Rad50
    cd18808
    Location:1068 → 1244
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd17936
    Location:971 → 1066
    EEXXEc_NFX1; EEXXE-box helicase domain of NFX1
    pfam01500
    Location:1425 → 1563
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam13086
    Location:897 → 1031
    AAA_11; AAA domain

  2. NM_001291162.2 → NP_001278091.1  NFX1-type zinc finger-containing protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AL591711
    Consensus CDS
    CCDS71198.1
    UniProtKB/TrEMBL
    A2A5R6
    Related
    ENSMUSP00000072867.6, ENSMUST00000067584.7
    Conserved Domains (4) summary
    cd06008
    Location:589 → 633
    NF-X1-zinc-finger; Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger ...
    COG1112
    Location:63 → 383
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam15042
    Location:626 → 690
    LELP1; Late cornified envelope-like proline-rich protein 1
    cl22977
    Location:180 → 363
    UvrD_C_2; UvrD-like helicase C-terminal domain

  3. NM_001424669.1 → NP_001411598.1  NFX1-type zinc finger-containing protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL591711
    UniProtKB/Swiss-Prot
    A2A5R3, Q3U016, Q3UD71, Q3UEZ0, Q8R151

  4. NM_001424676.1 → NP_001411605.1  NFX1-type zinc finger-containing protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL591711
    UniProtKB/Swiss-Prot
    A2A5R3, Q3U016, Q3UD71, Q3UEZ0, Q8R151

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    166877713..166904926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R151.3 GenPept UniProtKB/Swiss-Prot:Q8R151

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