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guaC GMP reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948986, updated on 4-Apr-2024

Summary

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Gene symbol
guaC
Gene description
GMP reductase
Primary source
ASAP:ABE-0000362
Locus tag
b0104
See related
ECOCYC:EG10422
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0104
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Genomic context

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Sequence:
NC_000913.3 (113444..114487)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cell division factor ZapD Neighboring gene dephospho-CoA kinase Neighboring gene protein YacM Neighboring gene inner membrane protein HofC Neighboring gene T2SSE family protein Neighboring gene prepilin-type N-terminal cleavage/methylation domain-containing protein PpdD

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Substrate and Cofactor Dynamics on Guanosine Monophosphate Reductase Probed by High Resolution Field Cycling 31P NMR Relaxometry. Rosenberg MM, et al. J Biol Chem, 2016 Oct 28. PMID 27613871, Free PMC Article
  2. Recombinant Escherichia coli GMP reductase: kinetic, catalytic and chemical mechanisms, and thermodynamics of enzyme-ligand binary complex formation. Martinelli LK, et al. Mol Biosyst, 2011 Apr. PMID 21298178
  3. Genetic and biochemical studies of the guanosine 5'-monophosphate pathway in Escherichia coli. Nijkamp HJ, et al. Biochim Biophys Acta, 1967 Aug 22. PMID 4861262
  4. Requirement of cyclic AMP for induction of GMP reductase in Escherichia coli. Benson CE, et al. Biochem Biophys Res Commun, 1971 Jun 4. PMID 4327955
  5. Cloning of the Escherichia coli K-12 guaC gene following its transposition into the RP4::Mu cointegrate. Moffat KG, et al. Gene, 1985. PMID 3005121

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. There are relative dynamics of substrate and cofactor exchange during the GMP reductase catalytic cycle.
    Title: Substrate and Cofactor Dynamics on Guanosine Monophosphate Reductase Probed by High Resolution Field Cycling 31P NMR Relaxometry.
  2. N-terminus verified by Edman degradation on complete protein
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables GMP reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GMP reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in IMP salvage IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within purine ribonucleotide interconversion IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of GMP reductase complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IC
Inferred by Curator
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
GMP reductase
NP_414646.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    113444..114487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414646.1 GMP reductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414646.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376MQV2
    Conserved Domains (1) summary
    PRK05096
    Location:1 → 346
    PRK05096; guanosine 5'-monophosphate oxidoreductase; Provisional
Nucleotide Protein
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