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tdcB catabolic threonine dehydratase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947633, updated on 4-Apr-2024

Summary

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Gene symbol
tdcB
Gene description
catabolic threonine dehydratase
Primary source
ASAP:ABE-0010249
Locus tag
b3117
See related
ECOCYC:EG10990
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3106; tdc
Summary
The structure of Salmonella typhimurium TcdB has been determined (Simanshu, 2006). otherPDB: [More information is available at EcoGene: EG10990]. Catabolic threonine dehydratase (TdcB) carries out the first step in threonine degradation and is one of several enzymes carrying out the first step in serine degradation. [More information is available at EcoCyc: EG10990].
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Genomic context

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Sequence:
NC_000913.3 (3265039..3266028, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene propionate kinase Neighboring gene threonine/serine:H(+) symporter Neighboring gene DNA-binding transcriptional activator TdcA Neighboring gene DNA-binding transcriptional activator TdcR

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystallization and preliminary X-ray crystallographic analysis of biodegradative threonine deaminase (TdcB) from Salmonella typhimurium. Simanshu DK, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 Mar 1. PMID 16511321, Free PMC Article
  2. NUCLEOTIDE ACTIVATION OF THREONINE DEAMINASE FROM ESCHERICHIA COLI. HIRATA M, et al. J Biol Chem, 1965 Apr. PMID 14285512
  3. Mechanism of catabolite inactivation of Escherichia coli biodegradative threonine dehydratase by glyoxylate. Park LS, et al. J Biol Chem, 1981 Jun 10. PMID 7016853
  4. Chemical characterization of biodegradative threonine dehydratases from two enteric bacteria. Kim SS, et al. Biochim Biophys Acta, 1982 Aug 23. PMID 6751404
  5. Synthesis of biodegradative threonine dehydratase in Escherichia coli: role of amino acids, electron acceptors, and certain intermediary metabolites. Hobert EH, et al. J Bacteriol, 1983 Aug. PMID 6348023, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Chemical characterization of biodegradative threonine dehydratases from two enteric bacteria.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables L-serine ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-serine ammonia-lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-serine ammonia-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables amino acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables threonine aldolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables threonine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables threonine deaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables threonine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-serine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within L-serine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-threonine catabolic process to propionate IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in isoleucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in threonine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within threonine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in threonine catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
catabolic threonine dehydratase
NP_417587.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3265039..3266028 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417587.1 catabolic threonine dehydratase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417587.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A826TAC1
    Conserved Domains (1) summary
    PRK08638
    Location:1 → 327
    PRK08638; bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB
Nucleotide Protein
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