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lgt phosphatidylglycerol--prolipoprotein diacylglyceryl transferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947303, updated on 6-Oct-2023

Summary

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Gene symbol
lgt
Gene description
phosphatidylglycerol--prolipoprotein diacylglyceryl transferase
Primary source
ASAP:ABE-0009270
Locus tag
b2828
See related
ECOCYC:EG12128
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2824; umpA
Summary
Sequence analysis, mutation, and expression studies show that lgt and the gene immediately downstream, thyA, form an operon . [More information is available at EcoCyc: EG12128].
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Genomic context

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Sequence:
NC_000913.3 (2965162..2966037, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene prepilin-type N-terminal cleavage/methylation domain-containing protein PpdB Neighboring gene prepilin-type N-terminal cleavage/methylation domain-containing protein PpdA Neighboring gene thymidylate synthase Neighboring gene phosphoenolpyruvate-protein phosphotransferase PtsP Neighboring gene RNA pyrophosphohydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Defect in Lipoprotein Modification by Lgt Leads to Abnormal Morphology and Cell Death in Escherichia coli That Is Independent of Major Lipoprotein Lpp. Legood S, et al. J Bacteriol, 2022 Sep 20. PMID 35938851, Free PMC Article
  2. Localization and characterization of prolipoprotein diacylglyceryl transferase (Lgt) critical in bacterial lipoprotein biosynthesis. Selvan AT, et al. Biochimie, 2008 Nov-Dec. PMID 18602442
  3. Roles of histidine-103 and tyrosine-235 in the function of the prolipoprotein diacylglyceryl transferase of Escherichia coli. Sankaran K, et al. J Bacteriol, 1997 May. PMID 9139912, Free PMC Article
  4. Structure-function relationship of bacterial prolipoprotein diacylglyceryl transferase: functionally significant conserved regions. Qi HY, et al. J Bacteriol, 1995 Dec. PMID 7592473, Free PMC Article
  5. Identification and genetic mapping of the structural gene for an essential Escherichia coli membrane protein. Williams MG, et al. J Bacteriol, 1989 Jan. PMID 2644208, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Defect in Lipoprotein Modification by Lgt Leads to Abnormal Morphology and Cell Death in Escherichia coli That Is Independent of Major Lipoprotein Lpp.
    Title: A Defect in Lipoprotein Modification by Lgt Leads to Abnormal Morphology and Cell Death in Escherichia coli That Is Independent of Major Lipoprotein Lpp.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipoprotein biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipoprotein biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipoprotein biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylglycerol--prolipoprotein diacylglyceryl transferase
NP_417305.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2965162..2966037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417305.1 phosphatidylglycerol--prolipoprotein diacylglyceryl transferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417305.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AF40, A0A830V0E2
    Conserved Domains (1) summary
    PRK00052
    Location:5 → 288
    PRK00052; prolipoprotein diacylglyceryl transferase; Reviewed
Nucleotide Protein
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