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minE Z-ring positioning protein MinE [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945740, updated on 23-Nov-2023

Summary

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Gene symbol
minE
Gene description
Z-ring positioning protein MinE
Primary source
ASAP:ABE-0003935
Locus tag
b1174
See related
ECOCYC:EG10598
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1162; minB
Summary
Overexpression causes filamentous biofilm formation and non-motility. [More information is available at EcoGene: EG10598]. MinE is an inhibitor of MinC, which is itself an inhibitor of septum formation. [More information is available at EcoCyc: EG10598].
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Genomic context

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Sequence:
NC_000913.3 (1224279..1224545, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein YmgJ Neighboring gene pseudo Neighboring gene Z-ring positioning protein MinD Neighboring gene Z-ring positioning protein MinC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The sequences of MinE responsible for its subcellular localization analyzed by competitive binding method in Escherichia coli. Pérez-Rodríguez MÁ, et al. Int Microbiol, 2018 Jun. PMID 30810919
  2. Direct MinE-membrane interaction contributes to the proper localization of MinDE in E. coli. Hsieh CW, et al. Mol Microbiol, 2010 Jan. PMID 20025670, Free PMC Article
  3. Self-organization of the MinE protein ring in subcellular Min oscillations. Derr J, et al. Phys Rev E Stat Nonlin Soft Matter Phys, 2009 Jul. PMID 19658744
  4. The topological specificity factor AtMinE1 is essential for correct plastid division site placement in Arabidopsis. Maple J, et al. Plant J, 2002 Aug. PMID 12164807
  5. The relationship between hetero-oligomer formation and function of the topological specificity domain of the Escherichia coli MinE protein. Zhang Y, et al. Mol Microbiol, 1998 Oct. PMID 9791172

See all (126) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Non-Equilibrium Large-Scale Membrane Transformations Driven by MinDE Biochemical Reaction Cycles.
    Title: Non-Equilibrium Large-Scale Membrane Transformations Driven by MinDE Biochemical Reaction Cycles.
  2. Investigated the exchange dynamics between major and excited states of the MinE dimer in 3 forms using 15N relaxation dispersion NMR.
    Title: Probing transient excited states of the bacterial cell division regulator MinE by relaxation dispersion NMR spectroscopy.
  3. The amino acid in the region (32-48) is sensitive to change MinE conformation and influence its dimerization.
    Title: The sequences of MinE responsible for its subcellular localization analyzed by competitive binding method in Escherichia coli.
  4. The MinDE reaction-diffusion system can dictate the localization of membrane proteins in a spatiotemporal manner without specific molecular interactions in vitro. These proteins apparently establish a generic, nucleotide-dependent transport mode for membrane-bound diffusive molecules based on a moving diffusion barrier.
    Title: The MinDE system is a generic spatial cue for membrane protein distribution in vitro.
  5. This review summarizes the cell-free data supporting a molecular mechanism that explains the variety of patterns supported by MinD and MinE both in and out of the cell; with an emphasis on the recent appreciation for how multiple conformational states of MinE can drive oscillation by spatiotemporally regulating MinD interaction with the membrane.
    Title: Mechanistic insights of the Min oscillator via cell-free reconstitution and imaging.
  6. the dynamic association of the MTS with the beta-sheet is fine-tuned to balance MinE's need to sense MinD on the membrane with its need to diffuse in the cytoplasm, both of which are necessary for the oscillation
    Title: MinE conformational dynamics regulate membrane binding, MinD interaction, and Min oscillation.
  7. Non-linear Min protein interactions generate harmonics that signal mid-cell division in Escherichia coli.
    Title: Non-linear Min protein interactions generate harmonics that signal mid-cell division in Escherichia coli.
  8. membrane targeting sequence defines the lower limit of the concentration-dependent wavelength of Min protein patterns while restraining MinE's ability to stimulate MinD's ATPase activity.
    Title: Large-scale modulation of reconstituted Min protein patterns and gradients by defined mutations in MinE's membrane targeting sequence.
  9. In the process of E. coli cell division, MinC-MinD copolymers bind to membrane, interact with FtsZ, and are disassembled by MinE.
    Title: MinCD cell division proteins form alternating copolymeric cytomotive filaments.
  10. Two MinD mutant proteins, MinD(K11A) and MinD(DeltaMTS15), are unable to form polymers with MinC
    Title: The bacterial cell division regulators MinD and MinC form polymers in the presence of nucleotide.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in division septum site selection IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within division septum site selection IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of cell division IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of division septum assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of division septum assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Z-ring positioning protein MinE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1224279..1224545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415692.1 Z-ring positioning protein MinE [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415692.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0A734
    Conserved Domains (1) summary
    PRK00296
    Location:1 → 86
    minE; cell division topological specificity factor MinE; Reviewed
Nucleotide Protein
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Research Materials