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talB transaldolase B [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944748, updated on 4-Apr-2024

Summary

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Gene symbol
talB
Gene description
transaldolase B
Primary source
ASAP:ABE-0000027
Locus tag
b0008
See related
ECOCYC:EG11556
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0008; yaaK
Summary
Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG11556]. Transaldolase B is an enzyme of the non-oxidative branch of the pentose phosphate pathway. [More information is available at EcoCyc: EG11556].
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Genomic context

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Sequence:
NC_000913.3 (8238..9191)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA binding and peroxide stress response protein YaaA Neighboring gene putative transporter YaaJ Neighboring gene molybdopterin adenylyltransferase Neighboring gene acetate/succinate:H(+) symporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel mode of inhibition by D-tagatose 6-phosphate through a Heyns rearrangement in the active site of transaldolase B variants. Stellmacher L, et al. Acta Crystallogr D Struct Biol, 2016 Apr. PMID 27050126
  2. Disruption of Escherichia coli transaldolase into catalytically active monomers: evidence against half-of-the-sites mechanism. Schörken U, et al. FEBS Lett, 1998 Dec 18. PMID 9883893
  3. Crystal structure of the reduced Schiff-base intermediate complex of transaldolase B from Escherichia coli: mechanistic implications for class I aldolases. Jia J, et al. Protein Sci, 1997 Jan. PMID 9007983, Free PMC Article
  4. Crystal structure of transaldolase B from Escherichia coli suggests a circular permutation of the alpha/beta barrel within the class I aldolase family. Jia J, et al. Structure, 1996 Jun 15. PMID 8805555
  5. Transaldolase B of Escherichia coli K-12: cloning of its gene, talB, and characterization of the enzyme from recombinant strains. Sprenger GA, et al. J Bacteriol, 1995 Oct. PMID 7592346, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. crystal structure of the variant TalB(F178Y) with bound sugar phosphate was solved to a resolution of 1.46 A and revealed a novel mode of covalent inhibition.
    Title: Novel mode of inhibition by D-tagatose 6-phosphate through a Heyns rearrangement in the active site of transaldolase B variants.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables transaldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transaldolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transaldolase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transketolase or transaldolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pentose-phosphate shunt, non-oxidative branch IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane HDA PubMed 

General protein information

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Preferred Names
transaldolase B
NP_414549.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    8238..9191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414549.1 transaldolase B [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414549.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7CSQ1, A0AA87G9Y5, A0AA94M9C6
    Conserved Domains (1) summary
    PRK05269
    Location:1 → 317
    PRK05269; transaldolase B; Provisional
Nucleotide Protein
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