FGF18 fibroblast growth factor 18 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FGF18provided by HGNC
Official Full Name: fibroblast growth factor 18provided by HGNC
Primary source: HGNC:HGNC:3674
See related: Ensembl:ENSG00000156427 MIM:603726; AllianceGenome:HGNC:3674
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZFGF5; FGF-18
Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]
Expression: Biased expression in heart (RPKM 3.7), lung (RPKM 0.9) and 12 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q35.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (171419647..171457626)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (171959977..171997979)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (170846651..170884630)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circulating FGF18 is decreased in pleural mesothelioma but not correlated with disease prognosis.
Title: Circulating FGF18 is decreased in pleural mesothelioma but not correlated with disease prognosis.
FGF18 promotes human lung branching morphogenesis through regulating mesenchymal progenitor cells.
Title: FGF18 promotes human lung branching morphogenesis through regulating mesenchymal progenitor cells.
FGF18-FGFR2 signaling triggers the activation of c-Jun-YAP1 axis to promote carcinogenesis in a subgroup of gastric cancer patients and indicates translational potential.
Title: FGF18-FGFR2 signaling triggers the activation of c-Jun-YAP1 axis to promote carcinogenesis in a subgroup of gastric cancer patients and indicates translational potential.
Identification of a genetic polymorphism in FGF18 significantly associated with the risk of Knee osteoarthritis based on samples with Chinese Han ancestry.
Title: Evaluation of Relationship Between Common Variants in FGF18 Gene and Knee Osteoarthritis Susceptibility.
The FGF18 is promising candidates for prognostic factors in adenocarcinomas of the esophago-gastric junction and new potential targets for new anti-cancer therapies.
Title: Expression of FGF8, FGF18, and FGFR4 in Gastroesophageal Adenocarcinomas.
The halo-recombinant human FGF18 promotes chondrocyte differentiation through ERK signaling pathway.
Title: Expression of Halo-hFGF18 and study of its effect on differentiation of ATDC5 cells.
EGR1 is a major upstream component of FGF signaling in theca cells and that it directs cell fate toward proliferation.
Title: Effects of fibroblast growth factors and the transcription factor, early growth response 1, on bovine theca cells.
In primary gastric cancer samples, FGF18 was overexpressed in genomically stable and chromosomal instability subtypes of GC. Overexpression was associated with poor survival. FGF18 knockdown inhibited tumor formation abilities, induced G1 phase cell cycle arrest, enhanced anti-cancer drug sensitivity, activated ATM pathway but quenched TGF-beta pathway. FGF18 was a direct target of tumor suppressor, miR-590-5p.
Title: FGF18, a prominent player in FGF signaling, promotes gastric tumorigenesis through autocrine manner and is negatively regulated by miR-590-5p.
High FGF18 expression is associated with angiogenesis in hepatocellular carcinoma.
Title: Ribosomal protein S15a promotes tumor angiogenesis via enhancing Wnt/β-catenin-induced FGF18 expression in hepatocellular carcinoma.
FGF18 played an important role in the growth and metastasis of breast cancer.
Title: Fibroblast growth factor 18 promotes the growth, migration and invasion of MDA‑MB‑231 cells.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

FGF18 (e-PCR)
- UniSTS:504846

bac5486T (e-PCR)
- UniSTS:181636

RH46294 (e-PCR)
- UniSTS:52909

G62751 (e-PCR)
- UniSTS:139728

FGF18_1325 (e-PCR)
- UniSTS:277237

FGF18_v410 (e-PCR)
- UniSTS:277237

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables type 1 fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 1 fibroblast growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables type 2 fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 2 fibroblast growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in anatomical structure morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in chondrocyte development	IEA Inferred from Electronic Annotation more info
involved_in endochondral ossification	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intramembranous ossification	IEA Inferred from Electronic Annotation more info
involved_in lung development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of blood vessel endothelial cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell chemotaxis to fibroblast growth factor	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in regulation of sprouting angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: fibroblast growth factor 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029158.1 RefSeqGene

Range

4985..42964

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_003862.3 → NP_003853.1 fibroblast growth factor 18 precursor

See identical proteins and their annotated locations for NP_003853.1

Status: REVIEWED

Source sequence(s)

AC093246, AF075292, BQ018759

Consensus CDS

CCDS4378.1

UniProtKB/Swiss-Prot

D3DQL7, O76093, Q6UWF1

UniProtKB/TrEMBL

A0A7U3JVY7

Related

ENSP00000274625.5, ENST00000274625.6

Conserved Domains (1) summary

pfam00167
Location:53 → 175

FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

171419647..171457626

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060929.1 Alternate T2T-CHM13v2.0

Range

171959977..171997979

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_033649.1: Suppressed sequence

Description

NM_033649.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.