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dagA PH domain-containing protein [ Dictyostelium discoideum AX4 ]

Gene ID: 8624989, updated on 27-Aug-2023

Summary

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Gene symbol
dagA
Gene description
PH domain-containing protein
Primary source
dictyBase:DDB_G0285161
Locus tag
DDB_G0285161
Gene type
protein coding
RNA name
cytosolic regulator of adenylyl cyclase
RefSeq status
PROVISIONAL
Organism
Dictyostelium discoideum AX4 (strain: AX4)
Lineage
Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium
Old locus tag
DDBDRAFT_0186392; DDBDRAFT_0191434; DDB_0186392; DDB_0191434
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Genomic context

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Location:
chromosome: 4
Exon count:
3
Sequence:
Chromosome: 4; NC_007090.3 (2973018..2975319, complement)

Chromosome 4 - NC_007090.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypoxanthine phosphoribosyltransferase Neighboring gene hypothetical protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007090.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Locally controlled inhibitory mechanisms are involved in eukaryotic GPCR-mediated chemosensing. Xu X, et al. J Cell Biol, 2007 Jul 2. PMID 17606871, Free PMC Article
  2. The PI3K-mediated activation of CRAC independently regulates adenylyl cyclase activation and chemotaxis. Comer FI, et al. Curr Biol, 2005 Jan 26. PMID 15668169
  3. Sensitization of Dictyostelium chemotaxis by phosphoinositide-3-kinase-mediated self-organizing signalling patches. Postma M, et al. J Cell Sci, 2004 Jun 15. PMID 15161938
  4. G protein signaling events are activated at the leading edge of chemotactic cells. Parent CA, et al. Cell, 1998 Oct 2. PMID 9778249
  5. CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium. Insall R, et al. J Cell Biol, 1994 Sep. PMID 8089184, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by dictyBase

Function Evidence Code Pubs
enables enzyme activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3,4-bisphosphate binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein kinase regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within aggregation involved in sorocarp development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphatidylinositol-mediated signaling TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within regulation of actin polymerization or depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sorocarp development HMP PubMed 
acts_upstream_of_or_within sporulation resulting in formation of a cellular spore TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in leading edge membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in macropinocytic cup IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic cup IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in pseudopodium IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Names
PH domain-containing protein
cytosolic regulator of adenylate cyclase
cytosolic regulator of adenylyl cyclase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007090.3 Reference assembly

    Range
    2973018..2975319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_633273.1 → XP_638365.1  cytosolic regulator of adenylyl cyclase [Dictyostelium discoideum AX4]

    See identical proteins and their annotated locations for XP_638365.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P35401, Q54NJ7
    Conserved Domains (2) summary
    smart00233
    Location:27 → 117
    PH; Pleckstrin homology domain
    pfam00169
    Location:28 → 122
    PH; PH domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q54NJ7.1

Gene LinkOut

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Molecular Biology Databases