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erkB ERK subfamily protein kinase [ Dictyostelium discoideum AX4 ]

Gene ID: 8624357, updated on 11-Apr-2024

Summary

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Gene symbol
erkB
Gene description
ERK subfamily protein kinase
Primary source
dictyBase:DDB_G0283903
Locus tag
DDB_G0283903
Gene type
protein coding
RNA name
extracellular response kinase
RefSeq status
PROVISIONAL
Organism
Dictyostelium discoideum AX4 (strain: AX4)
Lineage
Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium
Old locus tag
DDBDRAFT_0185780; DDBDRAFT_0191457; DDB_0185780; DDB_0191457
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Genomic context

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Location:
chromosome: 4
Exon count:
3
Sequence:
Chromosome: 4; NC_007090.3 (1385123..1386548, complement)

Chromosome 4 - NC_007090.3Genomic Context describing neighboring genes Neighboring gene DUF1754 family protein Neighboring gene GlcNAc transferase Neighboring gene hypothetical protein Neighboring gene PKA family protein kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007090.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Periodic signaling controlled by an oscillatory circuit that includes protein kinases ERK2 and PKA. Maeda M, et al. Science, 2004 May 7. PMID 15131307
  2. MAP kinase function in amoeboid chemotaxis. Wang Y, et al. J Cell Sci, 1998 Feb. PMID 9427685
  3. Chemoattractants induce tyrosine phosphorylation of ERK2 in Dictyostelium discoideum by diverse signalling pathways. Kosaka C, et al. Biochem J, 1997 May 15. PMID 9164876, Free PMC Article
  4. Seven helix chemoattractant receptors transiently stimulate mitogen-activated protein kinase in Dictyostelium. Role of heterotrimeric G proteins. Maeda M, et al. J Biol Chem, 1996 Feb 16. PMID 8631932
  5. The Dictyostelium MAP kinase ERK2 regulates multiple, independent developmental pathways. Gaskins C, et al. Genes Dev, 1996 Jan 1. PMID 8557190

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by dictyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables filamin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in aggregation involved in sorocarp development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in chemotaxis to cAMP IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chemotaxis to cAMP IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemotaxis to folate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oscillatory cAMP signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of macropinocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to cisplatin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to differentiation-inducing factor 1 HDA PubMed 
acts_upstream_of_or_within response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sorocarp spore cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol TAS
Traceable Author Statement
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Names
ERK subfamily protein kinase
MAP kinase
MAPK family protein kinase
extracellular response kinase
mitogen-activated protein kinase
protein serine/threonine kinase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007090.3 Reference assembly

    Range
    1385123..1386548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_633741.1 → XP_638833.1  extracellular response kinase [Dictyostelium discoideum AX4]

    See identical proteins and their annotated locations for XP_638833.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q54QB1, Q7M445
    Conserved Domains (2) summary
    smart00220
    Location:14 → 304
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07852
    Location:6 → 343
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
Nucleotide Protein
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