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SAP30 Sap30p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855305, updated on 11-Apr-2024

Summary

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Gene symbol
SAP30
Gene description
Sap30p
Primary source
SGD:S000004876
Locus tag
YMR263W
See related
AllianceGenome:SGD:S000004876
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables transcription corepressor activity. Involved in positive regulation of invasive growth in response to glucose limitation and regulation of gene expression. Part of Rpd3L complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (794919..795524)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene trehalose 6-phosphate synthase/phosphatase complex subunit Neighboring gene putative endodeoxyribonuclease Neighboring gene Cue1p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pho23 is associated with the Rpd3 histone deacetylase and is required for its normal function in regulation of gene expression and silencing in Saccharomyces cerevisiae. Loewith R, et al. J Biol Chem, 2001 Jun 29. PMID 11306585
  2. A promiscuous prion: efficient induction of [URE3] prion formation by heterologous prion domains. Ross CD, et al. Genetics, 2009 Nov. PMID 19752212, Free PMC Article
  3. Raf60, a novel component of the Rpd3 histone deacetylase complex required for Rpd3 activity in Saccharomyces cerevisiae. Colina AR, et al. J Biol Chem, 2005 Dec 30. PMID 16275642
  4. Identification of novel genes involved in neutral lipid storage by quantitative trait loci analysis of Saccharomyces cerevisiae. Pačnik K, et al. BMC Genomics, 2021 Feb 9. PMID 33563210, Free PMC Article
  5. The Yeast Prion [SWI(+)] Abolishes Multicellular Growth by Triggering Conformational Changes of Multiple Regulators Required for Flocculin Gene Expression. Du Z, et al. Cell Rep, 2015 Dec 29. PMID 26711350, Free PMC Article

See all (126) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of rDNA heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of silent mating-type cassette heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of invasive growth in response to glucose limitation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Rpd3L complex HDA PubMed 
part_of Rpd3L complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Rpd3L-Expanded complex HDA PubMed 
part_of histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sap30p
NP_013990.1
  • Component of Rpd3L histone deacetylase complex; involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    794919..795524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182770.1 → NP_013990.1  TPA: Sap30p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013990.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W089, P38429, Q03501
    UniProtKB/TrEMBL
    A0A8H4BWQ9, A6ZMX8, B3LMF0, B5VQ28, C7GR90, C8ZFC9, N1NXP9
    Conserved Domains (1) summary
    pfam13867
    Location:110 → 186
    SAP30_Sin3_bdg; Sin3 binding region of histone deacetylase complex subunit SAP30
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38429.2

Gene LinkOut

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