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RUP1 Rup1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854306, updated on 13-Apr-2024

Summary

Gene symbol
RUP1
Gene description
Rup1p
Primary source
SGD:S000005664
Locus tag
YOR138C
See related
AllianceGenome:SGD:S000005664
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in positive regulation of protein autoubiquitination and protein deubiquitination. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See RUP1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (584309..586324, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene isocitrate dehydrogenase (NAD(+)) IDH2 Neighboring gene Sia1p Neighboring gene Sfl1p Neighboring gene Arp8p

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of protein autoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Rup1p
NP_014781.1
  • Protein that regulates ubiquitination of Rsp5p; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    584309..586324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183557.1NP_014781.1  TPA: Rup1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014781.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2J5, Q12242
    UniProtKB/TrEMBL
    A0A8H4BX05, G2WN12, N1NWM7
    Conserved Domains (1) summary
    cd14307
    Location:441
    UBA_RUP1p; UBA domain found in yeast UBA domain-containing protein RUP1p and similar proteins