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CYT2 cytochrome c1 heme lyase CYT2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853775, updated on 13-Apr-2024

Summary

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Gene symbol
CYT2
Gene description
cytochrome c1 heme lyase CYT2
Primary source
SGD:S000001570
Locus tag
YKL087C
See related
AllianceGenome:SGD:S000001570
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables holocytochrome-c synthase activity. Involved in cytochrome c-heme linkage. Located in mitochondrial intermembrane space. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 1 and microphthalmia. Orthologous to human HCCS (holocytochrome c synthase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (277189..277863, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Mif2p Neighboring gene phosphopantothenoylcysteine decarboxylase complex subunit CAB3 Neighboring gene sulfiredoxin Neighboring gene malate dehydrogenase MDH1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of the Saccharomyces cerevisiae CYT2 gene, encoding cytochrome c1 heme lyase. Zollner A, et al. Curr Genet, 1994 Apr. PMID 8082171
  2. Molecular cloning and characterization of the Saccharomyces cerevisiae CYT2 gene encoding cytochrome-c1-heme lyase. Zollner A, et al. Eur J Biochem, 1992 Aug 1. PMID 1499554
  3. Heme binding to a conserved Cys-Pro-Val motif is crucial for the catalytic function of mitochondrial heme lyases. Steiner H, et al. J Biol Chem, 1996 Dec 20. PMID 8955088
  4. Biogenesis of mitochondrial heme lyases in yeast. Import and folding in the intermembrane space. Steiner H, et al. J Biol Chem, 1995 Sep 29. PMID 7559417
  5. On the specificity of cytochrome c synthetase in recognition of the amino acid sequence of apocytochrome c. Visco C, et al. J Biol Chem, 1985 May 25. PMID 2987215

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables holocytochrome-c synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables holocytochrome-c synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables holocytochrome-c synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytochrome c-heme linkage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytochrome c-heme linkage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome c1 heme lyase CYT2
NP_012836.1
  • Cytochrome c1 heme lyase; involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1; human homolog HCCS can complement yeast cyt2 null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    277189..277863 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179653.1 → NP_012836.1  TPA: cytochrome c1 heme lyase CYT2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012836.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXK1, Q00873
    UniProtKB/TrEMBL
    A0A8H4BXV4, A6ZZN1, B3LR05, B5VM71, C7GVM3, C8ZC87, G2WHU6
    Conserved Domains (1) summary
    pfam01265
    Location:57 → 218
    Cyto_heme_lyase; Cytochrome c/c1 heme lyase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00873.1

Gene LinkOut

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