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SRP21 signal recognition particle subunit SRP21 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853737, updated on 13-Apr-2024

Summary

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Gene symbol
SRP21
Gene description
signal recognition particle subunit SRP21
Primary source
SGD:S000001605
Locus tag
YKL122C
See related
AllianceGenome:SGD:S000001605
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable RNA binding activity. Involved in SRP-dependent cotranslational protein targeting to membrane. Located in nucleus. Part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SRP21 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (212495..212998, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene rDNA-binding RNA polymerase I transcriptional factor Neighboring gene Ssh4p Neighboring gene Dgr2p Neighboring gene Oac1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Misactivation of multiple starvation responses in yeast by loss of tRNA modifications. Bruch A, et al. Nucleic Acids Res, 2020 Jul 27. PMID 32484543, Free PMC Article
  2. Nuclear export of yeast signal recognition particle lacking Srp54p by the Xpo1p/Crm1p NES-dependent pathway. Ciufo LF, et al. Curr Biol, 2000 Oct 19. PMID 11069106
  3. Elongation arrest is a physiologically important function of signal recognition particle. Mason N, et al. EMBO J, 2000 Aug 1. PMID 10921896, Free PMC Article
  4. Subunits of the Saccharomyces cerevisiae signal recognition particle required for its functional expression. Brown JD, et al. EMBO J, 1994 Sep 15. PMID 7925282, Free PMC Article
  5. eIF5A has a function in the cotranslational translocation of proteins into the ER. Rossi D, et al. Amino Acids, 2014 Mar. PMID 24306454

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SRP-dependent cotranslational protein targeting to membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in SRP-dependent cotranslational protein targeting to membrane IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of signal recognition particle IEA
Inferred from Electronic Annotation
more info
  
part_of signal recognition particle, endoplasmic reticulum targeting IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal recognition particle, endoplasmic reticulum targeting IDA
Inferred from Direct Assay
more info
 PubMed 
part_of signal recognition particle, endoplasmic reticulum targeting IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
signal recognition particle subunit SRP21
NP_012800.1
  • Subunit of the signal recognition particle (SRP); SRP functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    212495..212998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179688.1 → NP_012800.1  TPA: signal recognition particle subunit SRP21 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012800.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXG8, P32342
    UniProtKB/TrEMBL
    A0A6A5PTK6, A6ZZJ7, B3LQX6, C8ZC53, G2WHR4, N1NZR1
    Conserved Domains (1) summary
    pfam05486
    Location:3 → 78
    SRP9-21; Signal recognition particle 9 kDa protein (SRP9)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32342.3

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