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MYO3 myosin 3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853729, updated on 13-Apr-2024

Summary

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Gene symbol
MYO3
Gene description
myosin 3
Primary source
SGD:S000001612
Locus tag
YKL129C
See related
AllianceGenome:SGD:S000001612
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable actin filament binding activity and microfilament motor activity. Involved in actin cortical patch localization and positive regulation of Arp2/3 complex-mediated actin nucleation. Located in cell periphery. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 6. Orthologous to human MYO1E (myosin IE) and MYO1F (myosin IF). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (196349..200167, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene putative tetrahydrofolate synthase Neighboring gene She2p Neighboring gene putative phosphomutase Neighboring gene tRNA-Lys

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and molecular characterization of a yeast myosin I. Goodson HV, et al. Cell Motil Cytoskeleton, 1995. PMID 7728870
  2. Regulation of membrane scission in yeast endocytosis. Menon D, et al. Mol Biol Cell, 2022 Oct 1. PMID 35976707, Free PMC Article
  3. New approaches to high-throughput structure characterization of SH3 complexes: the example of Myosin-3 and Myosin-5 SH3 domains from S. cerevisiae. Musi V, et al. Protein Sci, 2006 Apr. PMID 16600966, Free PMC Article
  4. Role of type I myosins in receptor-mediated endocytosis in yeast. Geli MI, et al. Science, 1996 Apr 26. PMID 8614799
  5. Verprolin cytokinesis function mediated by the Hof one trap domain. Ren G, et al. Traffic, 2005 Jul. PMID 15941409

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cortical patch localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cortical patch localization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bipolar cellular bud site selection TAS
Traceable Author Statement
more info
 PubMed 
involved_in cellular component organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular localization IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis TAS
Traceable Author Statement
more info
 PubMed 
involved_in exocytosis TAS
Traceable Author Statement
more info
 PubMed 
involved_in fungal-type cell wall organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to osmotic stress TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within reticulophagy IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cortical patch IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cortical patch IEA
Inferred from Electronic Annotation
more info
  
located_in actin cortical patch TAS
Traceable Author Statement
more info
 PubMed 
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell periphery HDA PubMed 
is_active_in cell tip IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myosin 3
NP_012793.2
  • One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO3 has a paralog, MYO5, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    196349..200167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179695.2 → NP_012793.2  TPA: myosin 3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012793.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZZJ1, D6VX66, P36006
    UniProtKB/TrEMBL
    A0A8H4BXV0, C8ZC46, G2WHQ8, N1P0R3
    Conserved Domains (1) summary
    COG5022
    Location:1 → 1258
    COG5022; Myosin heavy chain [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36006.4

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