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TAN1 putative tRNA acetyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852619, updated on 13-Apr-2024

Summary

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Gene symbol
TAN1
Gene description
putative tRNA acetyltransferase
Primary source
SGD:S000003201
Locus tag
YGL232W
See related
AllianceGenome:SGD:S000003201
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA binding activity. Involved in tRNA modification. Located in cytoplasm and nucleus. Orthologous to human THUMPD1 (THUMP domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VII
Exon count:
2
Sequence:
Chromosome: VII; NC_001139.9 (62075..63002)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase Neighboring gene Rab GTPase-binding exocyst subunit SEC15 Neighboring gene chaperone EMC4 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Saccharomyces cerevisiae TAN1 gene is required for N4-acetylcytidine formation in tRNA. Johansson MJ, et al. RNA, 2004 Apr. PMID 15037780, Free PMC Article
  2. Mechanism for the degradation of origin recognition complex containing Orc5p with a defective Walker A motif and its suppression by over-production of Orc4p in yeast cells. Makise M, et al. Biochem J, 2007 Mar 1. PMID 17107343, Free PMC Article
  3. Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping. Sas-Chen A, et al. Nature, 2020 Jul. PMID 32555463, Free PMC Article
  4. Role of Saccharomyces cerevisiae TAN1 (tRNA acetyltransferase) in eukaryotic initiation factor 2B (eIF2B)-mediated translation control and stress response. Sharma S, et al. 3 Biotech, 2017 Jul. PMID 28677085, Free PMC Article
  5. Identification of yeast tRNA Um(44) 2'-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNA(Ser) species. Kotelawala L, et al. RNA, 2008 Jan. PMID 18025252, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA modification IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative tRNA acetyltransferase
NP_011282.1
  • Adaptor in Kre33p-mediated N4-acetylcytidine modification of tRNAs; tRNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine (ac4C) in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress; contains a conserved THUMP domain, and is homologous to human THUMPD1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    62075..63002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181098.1 → NP_011282.1  TPA: putative tRNA acetyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011282.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVA2, P53072
    UniProtKB/TrEMBL
    A6ZTV8, B3LHS5, C7GNX9, C8Z823, G2WDM7, N1P9V3
    Conserved Domains (1) summary
    cd11717
    Location:113 → 259
    THUMP_THUMPD1_like; THUMP domain-containing protein 1-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53072.1

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