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TAE1 N-terminal protein methyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852564, updated on 13-Apr-2024

Summary

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Gene symbol
TAE1
Gene description
N-terminal protein methyltransferase
Primary source
SGD:S000000465
Locus tag
YBR261C
See related
AllianceGenome:SGD:S000000465
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NTM1
Summary
Enables N-terminal protein N-methyltransferase activity. Involved in N-terminal peptidyl-proline dimethylation and cytoplasmic translation. Located in cytosol. Orthologous to several human genes including NTMT1 (N-terminal Xaa-Pro-Lys N-methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (734832..735530, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene GTPase-activating protein RGD1 Neighboring gene Mic12p Neighboring gene glycine hydroxymethyltransferase SHM1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Discovering the N-Terminal Methylome by Repurposing of Proteomic Datasets. Chen P, et al. J Proteome Res, 2021 Sep 3. PMID 34382793
  2. Identification of protein N-terminal methyltransferases in yeast and humans. Webb KJ, et al. Biochemistry, 2010 Jun 29. PMID 20481588, Free PMC Article
  3. Ribosomal protein methyltransferases in the yeast Saccharomyces cerevisiae: Roles in ribosome biogenesis and translation. Al-Hadid Q, et al. Biochem Biophys Res Commun, 2016 Feb 12. PMID 26801560, Free PMC Article
  4. Chemical-genetic profile analysis in yeast suggests that a previously uncharacterized open reading frame, YBR261C, affects protein synthesis. Alamgir M, et al. BMC Genomics, 2008 Dec 3. PMID 19055778, Free PMC Article
  5. DBP7 and YRF1-6 Are Involved in Cell Sensitivity to LiCl by Regulating the Translation of PGM2 mRNA. Jagadeesan SK, et al. Int J Mol Sci, 2023 Jan 16. PMID 36675300, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. deletion of YBR261C alters the ribosomal profile of the mutant cells. Also, gene deletion strain for YBR261C has defects in both translation efficiency and fidelity
    Title: Chemical-genetic profile analysis in yeast suggests that a previously uncharacterized open reading frame, YBR261C, affects protein synthesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables N-terminal protein N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-terminal protein N-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-terminal protein N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables N-terminal protein N-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-terminal peptidyl-proline dimethylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in N-terminal peptidyl-proline dimethylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in N-terminal protein amino acid methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cytoplasmic translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
N-terminal protein methyltransferase
NP_009820.1
  • AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    734832..735530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178609.1 → NP_009820.1  TPA: N-terminal protein methyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009820.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQQ8, P38340
    UniProtKB/TrEMBL
    A0A6A5Q1G7, A6ZLK1, B3LMQ0, B5VEL0, C7GMW9, D3UF09, G2W9R6, N1P8T9
    Conserved Domains (1) summary
    pfam05891
    Location:6 → 228
    Methyltransf_PK; AdoMet dependent proline di-methyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38340.1

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