POP4 RNase P/RNase MRP complex subunit [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: POP4
Gene description: RNase P/RNase MRP complex subunit
Primary source: SGD:S000000461
Locus tag: YBR257W
See related: AllianceGenome:SGD:S000000461
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables rRNA primary transcript binding activity. Contributes to ribonuclease MRP activity and ribonuclease P activity. Involved in RNA metabolic process. Part of nucleolar ribonuclease P complex and ribonuclease MRP complex. Orthologous to human POP4 (POP4 homolog, ribonuclease P/MRP subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

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Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP.
Title: Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables rRNA primary transcript binding	IDA Inferred from Direct Assay more info	PubMed
enables ribonuclease P RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribonuclease P RNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intronic box C/D snoRNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in ncRNA processing	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process, RNase MRP-dependent	IDA Inferred from Direct Assay more info	PubMed
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in rRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA 5'-leader removal	IEA Inferred from Electronic Annotation more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in tRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of nucleolar ribonuclease P complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonuclease MRP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonuclease MRP complex	IDA Inferred from Direct Assay more info	PubMed
part_of ribonuclease MRP complex	IEA Inferred from Electronic Annotation more info
part_of ribonuclease MRP complex	IPI Inferred from Physical Interaction more info	PubMed
part_of ribonuclease P complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonuclease P complex	IDA Inferred from Direct Assay more info	PubMed
part_of ribonuclease P complex	IEA Inferred from Electronic Annotation more info

NP_009816.1

Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P

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