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NGR1 Ngr1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852513, updated on 11-Apr-2024

Summary

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Gene symbol
NGR1
Gene description
Ngr1p
Primary source
SGD:S000000416
Locus tag
YBR212W
See related
AllianceGenome:SGD:S000000416
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RBP1
Summary
Enables mRNA binding activity. Involved in 3'-UTR-mediated mRNA destabilization and mitochondrion organization. Located in P-body; cytoplasmic stress granule; and perinuclear region of cytoplasm. Orthologous to human TIA1 (TIA1 cytotoxic granule associated RNA binding protein); TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1); and TRNAU1AP (tRNA selenocysteine 1 associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (647886..649904)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Erv15p Neighboring gene Ame1p Neighboring gene bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8 Neighboring gene Sds24p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The yeast RNA-binding protein Rbp1p modifies the stability of mitochondrial porin mRNA. Buu LM, et al. J Biol Chem, 2004 Jan 2. PMID 14570877
  2. CTBP1/RBP1, a Saccharomyces cerevisiae protein which binds to T-rich single-stranded DNA containing the 11-bp core sequence of autonomously replicating sequence, is a poly(deoxypyrimidine)-binding protein. Ikeda M, et al. Eur J Biochem, 1996 May 15. PMID 8665950
  3. An RNA-binding protein gene (RBP1) of Saccharomyces cerevisiae encodes a putative glucose-repressible protein containing two RNA recognition motifs. Lee FJ, et al. J Biol Chem, 1993 Jul 15. PMID 8325883
  4. Determinants of Rbp1p localization in specific cytoplasmic mRNA-processing foci, P-bodies. Jang LT, et al. J Biol Chem, 2006 Sep 29. PMID 16885161
  5. Identification of genes affecting glucose catabolism in nitrogen-limited fermentation. Gardner JM, et al. FEMS Yeast Res, 2005 Jun. PMID 15925307

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding HDA PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 3'-UTR-mediated mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasmic stress granule HDA PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Ngr1p
NP_009771.3
  • RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; interacts with Dhh1p to mediate POR1 mRNA decay; expressed in stationary phase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    647886..649904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178560.3 → NP_009771.3  TPA: Ngr1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009771.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQK8, P32831
    UniProtKB/TrEMBL
    A0A8H4BTN2, B3LMU8, C7GUY4, D3UEV8
    Conserved Domains (4) summary
    COG0724
    Location:308 → 526
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12346
    Location:359 → 430
    RRM3_NGR1_NAM8_like; RNA recognition motif 3 (RRM3) found in yeast negative growth regulatory protein NGR1 (RBP1), yeast protein NAM8 and similar proteins
    cd12611
    Location:35 → 180
    RRM1_NGR1_NAM8_like; RNA recognition motif 1 (RRM1) found in yeast negative growth regulatory protein NGR1, yeast protein NAM8 and similar proteins
    cd12613
    Location:191 → 270
    RRM2_NGR1_NAM8_like; RNA recognition motif 2 (RRM2) found in yeast negative growth regulatory protein NGR1, yeast protein NAM8 and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32831.2

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