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BAP2 branched-chain amino acid permease BAP2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852360, updated on 13-Apr-2024

Summary

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Gene symbol
BAP2
Gene description
branched-chain amino acid permease BAP2
Primary source
SGD:S000000272
Locus tag
YBR068C
See related
AllianceGenome:SGD:S000000272
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables amino acid transmembrane transporter activity. Involved in amino acid transport and transmembrane transport. Located in plasma membrane. Orthologous to several human genes including SLC7A1 (solute carrier family 7 member 1); SLC7A2 (solute carrier family 7 member 2); and SLC7A3 (solute carrier family 7 member 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (373861..375690, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Nrg2p Neighboring gene putative lipase Neighboring gene amino acid transporter TAT1 Neighboring gene ncRNA Neighboring gene N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase anchoring subunit ALG14

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Linking gene expression and oenological traits: Comparison between Torulaspora delbrueckii and Saccharomyces cerevisiae strains. Tondini F, et al. Int J Food Microbiol, 2019 Apr 2. PMID 30763906
  2. The N-terminal domain of the yeast permease Bap2p plays a role in its degradation. Omura F, et al. Biochem Biophys Res Commun, 2001 Oct 12. PMID 11587526
  3. The basal turnover of yeast branched-chain amino acid permease Bap2p requires its C-terminal tail. Omura F, et al. FEMS Microbiol Lett, 2001 Jan 15. PMID 11164310
  4. The branched-chain amino acid permease gene of Saccharomyces cerevisiae, BAP2, encodes the high-affinity leucine permease (S1). Schreve J, et al. Yeast, 1997 Apr. PMID 9153753
  5. Amino acids induce expression of BAP2, a branched-chain amino acid permease gene in Saccharomyces cerevisiae. Didion T, et al. J Bacteriol, 1996 Apr. PMID 8606179, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel function of transcription factor Uga3 as an activator of branched-chain amino acid permease BAP2 gene expression.
    Title: Novel function of transcription factor Uga3 as an activator of branched-chain amino acid permease BAP2 gene expression.
  2. A regulatory circuit between lncRNA and TOR directs amino acid uptake in yeast.
    Title: A regulatory circuit between lncRNA and TOR directs amino acid uptake in yeast.
  3. Using in silico analyses and mutational studies we found that the C-terminal sequences of Gap1, Bap2, Hip1, Tat1, Tat2, Mmp1, Sam3, Agp1, and Gnp1 are about 50 residues long, associate with the Plasma Membrane , and have features that discriminate them from the termini of organellar amino acid transporters
    Title: A Plasma Membrane Association Module in Yeast Amino Acid Transporters.
  4. Ist2 in the yeast cortical endoplasmic reticulum promotes trafficking of the amino acid transporter Bap2 to the plasma membrane.
    Title: Ist2 in the yeast cortical endoplasmic reticulum promotes trafficking of the amino acid transporter Bap2 to the plasma membrane.
  5. The substrate partition efficiency to the buried Bap2 binding pocket is the primary determinant of substrate specificity.
    Title: Functional mapping and implications of substrate specificity of the yeast high-affinity leucine permease Bap2.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nitrogen compound transport IEA
Inferred from Electronic Annotation
more info
  
involved_in organic substance transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phenylalanine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
branched-chain amino acid permease BAP2
NP_009624.4
  • High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    373861..375690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178416.4 → NP_009624.4  TPA: branched-chain amino acid permease BAP2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009624.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ67, P38084
    UniProtKB/TrEMBL
    A0A6A5Q1T6, A6ZL12, B3LN81, B5VE33, G2W973
    Conserved Domains (1) summary
    TIGR00913
    Location:92 → 573
    2A0310; amino acid permease (yeast)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38084.2

Gene LinkOut

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