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UGO1 Ugo1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852081, updated on 13-Apr-2024

Summary

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Gene symbol
UGO1
Gene description
Ugo1p
Primary source
SGD:S000002878
Locus tag
YDR470C
See related
AllianceGenome:SGD:S000002878
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable thiamine transmembrane transporter activity. Involved in mitochondrial fusion. Is integral component of mitochondrial outer membrane. Used to study Leigh disease. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1399706..1401214, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Tlg1p Neighboring gene Sdc1p Neighboring gene ribosomal 60S subunit protein L27B Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondrial outer and inner membrane fusion requires a modified carrier protein. Hoppins S, et al. J Cell Biol, 2009 Feb 23. PMID 19237599, Free PMC Article
  2. Ugo1p is a multipass transmembrane protein with a single carrier domain required for mitochondrial fusion. Coonrod EM, et al. Traffic, 2007 May. PMID 17451553
  3. SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome. Janer A, et al. EMBO Mol Med, 2016 Sep. PMID 27390132, Free PMC Article
  4. UGO1 encodes an outer membrane protein required for mitochondrial fusion. Sesaki H, et al. J Cell Biol, 2001 Mar 19. PMID 11257114, Free PMC Article
  5. The fusogenic lipid phosphatidic acid promotes the biogenesis of mitochondrial outer membrane protein Ugo1. Vögtle FN, et al. J Cell Biol, 2015 Sep 14. PMID 26347140, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reconstituted the import and assembly pathway of Ugo1 in protein-free liposomes, mimicking the outer membrane phospholipid composition, and found a direct dependency of Ugo1 biogenesis on phosphatidic acid.
    Title: The fusogenic lipid phosphatidic acid promotes the biogenesis of mitochondrial outer membrane protein Ugo1.
  2. Ugo1 is inserted into the MOM by a novel pathway in which Tom70 and Mim1 contribute to the efficiency and selectivity of the process.
    Title: Multispan mitochondrial outer membrane protein Ugo1 follows a unique Mim1-dependent import pathway.
  3. Fzo1 assembles into homo-dimers, depending on Ugo1 and on GTP binding to Fzo1.
    Title: Ugo1 and Mdm30 act sequentially during Fzo1-mediated mitochondrial outer membrane fusion.
  4. Findings demonstrate that Ugo1 plays a unique, postmembrane tethering role in mitochondrial fusion.
    Title: Mitochondrial outer and inner membrane fusion requires a modified carrier protein.
  5. PCD2 was identified as a functional (fusion)domain of Ugo1p thata contains at least one additional transmembrane domain that mediates outer membrame targeting and fusion.
    Title: Ugo1p is a multipass transmembrane protein with a single carrier domain required for mitochondrial fusion.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial outer membrane HDA PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ugo1p
NP_010758.3
  • Outer membrane component of the mitochondrial fusion machinery; binds to Fzo1p and Mgm1p to link these two GTPases during mitochondrial fusion; involved in fusion of both the outer and inner membranes; facilitates dimerization of Fzo1p during fusion; import into the outer membrane is mediated by Tom70p and Mim1p; has similarity to carrier proteins but likely not a transporter; similar to human SLC25A46 implicated in optic atroprophy spectrum disorder and Leigh syndrome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1399706..1401214 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180778.2 → NP_010758.3  TPA: Ugo1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010758.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT94, Q03327
    UniProtKB/TrEMBL
    A0A8H8UP03, B3LFJ5, C8Z629, N1P7C5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03327.3

Gene LinkOut

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