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KEI1 Kei1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851973, updated on 11-Apr-2024

Summary

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Gene symbol
KEI1
Gene description
Kei1p
Primary source
SGD:S000002775
Locus tag
YDR367W
See related
AllianceGenome:SGD:S000002775
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables inositol phosphoceramide synthase regulator activity. Involved in inositol phosphoceramide metabolic process. Is integral component of Golgi membrane. Part of inositol phosphoceramide synthase complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
2
Sequence:
Chromosome: IV; NC_001136.10 (1212848..1213614)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene Mor1p Neighboring gene trifunctional aldehyde reductase/carbonyl reductase (NADPH)/glucose 1-dehydrogenase (NADP(+)) YPR1 Neighboring gene Xrs2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kei1: a novel subunit of inositolphosphorylceramide synthase, essential for its enzyme activity and Golgi localization. Sato K, et al. Mol Biol Cell, 2009 Oct. PMID 19726565, Free PMC Article
  2. Auxin-Inducible Depletion of the Essentialome Suggests Inhibition of TORC1 by Auxins and Inhibition of Vrg4 by SDZ 90-215, a Natural Antifungal Cyclopeptide. Snyder NA, et al. G3 (Bethesda), 2019 Mar 7. PMID 30670608, Free PMC Article
  3. Orm proteins integrate multiple signals to maintain sphingolipid homeostasis. Gururaj C, et al. J Biol Chem, 2013 Jul 12. PMID 23737533, Free PMC Article
  4. Assigning function to yeast proteins by integration of technologies. Hazbun TR, et al. Mol Cell, 2003 Dec. PMID 14690591
  5. Functional profiling of the Saccharomyces cerevisiae genome. Giaever G, et al. Nature, 2002 Jul 25. PMID 12140549

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables inositol phosphoceramide synthase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol phosphoceramide synthase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol phosphoceramide synthase regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in inositol phosphoceramide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inositol phosphoceramide metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in inositol phosphoceramide metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus HDA PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm HDA PubMed 
part_of inositol phosphoceramide synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of inositol phosphoceramide synthase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Kei1p
NP_010655.1
  • Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1212848..1213614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180675.1 → NP_010655.1  TPA: Kei1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010655.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSZ8, Q06346, Q06999
    UniProtKB/TrEMBL
    A6ZYW5, C7GMH0, C8Z5S8, G2WBA3, N1P5D5
    Conserved Domains (1) summary
    pfam08552
    Location:11 → 182
    Kei1; Inositolphosphorylceramide synthase subunit Kei1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06346.2

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