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BPL1 biotin--[acetyl-CoA-carboxylase] ligase BPL1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851414, updated on 11-Apr-2024

Summary

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Gene symbol
BPL1
Gene description
biotin--[acetyl-CoA-carboxylase] ligase BPL1
Primary source
SGD:S000002300
Locus tag
YDL141W
See related
AllianceGenome:SGD:S000002300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ACC2
Summary
Enables biotin-[acetyl-CoA-carboxylase] ligase activity and biotin-[pyruvate-carboxylase] ligase activity. Involved in protein biotinylation. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in holocarboxylase synthetase deficiency. Orthologous to human HLCS (holocarboxylase synthetase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (203039..205111)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene chaperonin-containing T-complex subunit CCT4 Neighboring gene cardiolipin synthase Neighboring gene DNA-directed RNA polymerase II core subunit RPO21 Neighboring gene Scm3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expanding the substrate tolerance of biotin ligase through exploration of enzymes from diverse species. Slavoff SA, et al. J Am Chem Soc, 2008 Jan 30. PMID 18171066, Free PMC Article
  2. Expression, purification, crystallization and preliminary phasing of the heteromerization domain of the tRNA-export and aminoacylation cofactor Arc1p from yeast. Simader H, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 Apr 1. PMID 16582481, Free PMC Article
  3. Biotin protein ligase from Saccharomyces cerevisiae. The N-terminal domain is required for complete activity. Polyak SW, et al. J Biol Chem, 1999 Nov 12. PMID 10551847
  4. Identification of the tRNA-binding protein Arc1p as a novel target of in vivo biotinylation in Saccharomyces cerevisiae. Kim HS, et al. J Biol Chem, 2004 Oct 8. PMID 15272000
  5. Pleiotropic phenotype of acetyl-CoA-carboxylase-defective yeast cells--viability of a BPL1-amber mutation depending on its readthrough by normal tRNA(Gln)(CAG). Hoja U, et al. Eur J Biochem, 1998 Jun 15. PMID 9688262

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structure-guided inhibitor design for human acetyl-coenzyme A carboxylase by interspecies active site conversion.
    Title: Structure-guided inhibitor design for human acetyl-coenzyme A carboxylase by interspecies active site conversion.
  2. presence of 20 monomers organized in five tetramers per asymmetric unit.
    Title: Expression, purification, crystallization and preliminary phasing of the heteromerization domain of the tRNA-export and aminoacylation cofactor Arc1p from yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables biotin-[acetyl-CoA-carboxylase] ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables biotin-[acetyl-CoA-carboxylase] ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables biotin-[acetyl-CoA-carboxylase] ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables biotin-[pyruvate-carboxylase] ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein modification process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein modification process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
biotin--[acetyl-CoA-carboxylase] ligase BPL1
NP_010140.1
  • Biotin:apoprotein ligase; covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon; human homolog HLCS can complement yeast BPL1 mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    203039..205111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180201.1 → NP_010140.1  TPA: biotin--[acetyl-CoA-carboxylase] ligase BPL1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010140.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRK7, P48445
    UniProtKB/TrEMBL
    A0A8H8UMF3, G2WC20, N1P610
    Conserved Domains (2) summary
    COG0340
    Location:388 → 680
    BirA2; Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]
    pfam09825
    Location:2 → 374
    BPL_N; Biotin-protein ligase, N terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48445.1

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