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ACK1 Ack1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851324, updated on 3-Dec-2023

Summary

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Gene symbol
ACK1
Gene description
Ack1p
Primary source
SGD:S000002362
Locus tag
YDL203C
See related
AllianceGenome:SGD:S000002362
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in fungal-type cell wall organization and positive regulation of signal transduction. Located in mitochondrion. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human DELE1 (DAP3 binding cell death enhancer 1); SEL1L (SEL1L adaptor subunit of ERAD E3 ubiquitin ligase); and SEL1L2 (SEL1L2 adaptor subunit of ERAD E3 ligase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ACK1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (96082..97953, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene hydroxymethylbilane synthase Neighboring gene Rtn2p Neighboring gene mitochondrial 54S ribosomal protein YmL11 Neighboring gene tRNA (guanine46-N7)-methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The functional relationships underlying a synthetic genetic network. Krause SA, et al. Commun Integr Biol, 2009. PMID 19704853, Free PMC Article
  2. A high throughput screen to identify substrates for the ubiquitin ligase Rsp5. Kus B, et al. J Biol Chem, 2005 Aug 19. PMID 15955809
  3. The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose. Defenouillère Q, et al. Sci Signal, 2019 Sep 3. PMID 31481524
  4. Plant-derived antifungal agent poacic acid targets β-1,3-glucan. Piotrowski JS, et al. Proc Natl Acad Sci U S A, 2015 Mar 24. PMID 25775513, Free PMC Article
  5. The synthetic genetic network around PKC1 identifies novel modulators and components of protein kinase C signaling in Saccharomyces cerevisiae. Krause SA, et al. Eukaryot Cell, 2008 Nov. PMID 18806213, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
Ack1p
NP_010078.1
  • Protein that functions in the cell wall integrity pathway; functions upstream of Pkc1p; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    96082..97953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180263.1 → NP_010078.1  TPA: Ack1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010078.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRF1, Q07622
    UniProtKB/TrEMBL
    A0A8H8UM98, G2WBW4, N1P8D5
    Conserved Domains (3) summary
    smart00671
    Location:318 → 361
    SEL1; Sel1-like repeats
    COG0790
    Location:342 → 623
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:345 → 374
    SLR; SLR repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07622.1

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