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LIP2 lipoyl(octanoyl) transferase LIP2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850940, updated on 13-Apr-2024

Summary

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Gene symbol
LIP2
Gene description
lipoyl(octanoyl) transferase LIP2
Primary source
SGD:S000004229
Locus tag
YLR239C
See related
AllianceGenome:SGD:S000004229
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ligase activity. Involved in protein lipoylation. Located in mitochondrion. Used to study glycine encephalopathy. Orthologous to human LIPT2 (lipoyl(octanoyl) transferase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (616332..617318, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene thiamine transporter THI7 Neighboring gene Far10p Neighboring gene phosphatidylinositol 3-kinase VPS34 Neighboring gene Csc1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The isolation and characterisation of a Saccharomyces cerevisiae gene (LIP2) involved in the attachment of lipoic acid groups to mitochondrial enzymes. Marvin ME, et al. FEMS Microbiol Lett, 2001 May 15. PMID 11356580
  2. A role for the succinate dehydrogenase in the mode of action of the redox-active antimalarial drug, plasmodione. Mounkoro P, et al. Free Radic Biol Med, 2021 Jan. PMID 33232753
  3. Biallelic Mutations in LIPT2 Cause a Mitochondrial Lipoylation Defect Associated with Severe Neonatal Encephalopathy. Habarou F, et al. Am J Hum Genet, 2017 Aug 3. PMID 28757203, Free PMC Article
  4. The role of the Saccharomyces cerevisiae lipoate protein ligase homologue, Lip3, in lipoic acid synthesis. Hermes FA, et al. Yeast, 2013 Oct. PMID 23960015, Free PMC Article
  5. Lipoic acid synthesis and attachment in yeast mitochondria. Schonauer MS, et al. J Biol Chem, 2009 Aug 28. PMID 19570983, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables lipoyl(octanoyl) transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipoyl(octanoyl) transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein lipoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein lipoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lipoyl(octanoyl) transferase LIP2
NP_013340.1
  • Lipoyl ligase; involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    616332..617318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182126.1 → NP_013340.1  TPA: lipoyl(octanoyl) transferase LIP2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013340.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYN7, Q06005
    UniProtKB/TrEMBL
    A0A8H4BYT0, A7A1C2, B3RHC4, C7GQZ7, G2WJ65, N1NYF9
    Conserved Domains (1) summary
    cl14057
    Location:90 → 309
    BPL_LplA_LipB; biotin-lipoate ligase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06005.1

Gene LinkOut

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