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CDC123 cell proliferation protein CDC123 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850912, updated on 13-Apr-2024

Summary

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Gene symbol
CDC123
Gene description
cell proliferation protein CDC123
Primary source
SGD:S000004205
Locus tag
YLR215C
See related
AllianceGenome:SGD:S000004205
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable ATP binding activity and magnesium ion binding activity. Involved in eukaryotic translation initiation factor 2 complex assembly and positive regulation of translational initiation. Located in cytoplasm. Orthologous to human CDC123 (cell division cycle 123). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (570776..571858, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene putative glycosylase Neighboring gene ferric/cupric-chelate reductase Neighboring gene peptidylprolyl isomerase CPR6 Neighboring gene Coa4p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cdc123, a Cell Cycle Regulator Needed for eIF2 Assembly, Is an ATP-Grasp Protein with Unique Features. Panvert M, et al. Structure, 2015 Sep 1. PMID 26211610
  2. Cdc123 and checkpoint forkhead associated with RING proteins control the cell cycle by controlling eIF2gamma abundance. Bieganowski P, et al. J Biol Chem, 2004 Oct 22. PMID 15319434
  3. Translation initiation requires cell division cycle 123 (Cdc123) to facilitate biogenesis of the eukaryotic initiation factor 2 (eIF2). Perzlmaier AF, et al. J Biol Chem, 2013 Jul 26. PMID 23775072, Free PMC Article
  4. Stepwise assembly of the eukaryotic translation initiation factor 2 complex. Vanselow S, et al. J Biol Chem, 2022 Feb. PMID 35031321, Free PMC Article
  5. Evolution. Systematic humanization of yeast genes reveals conserved functions and genetic modularity. Kachroo AH, et al. Science, 2015 May 22. PMID 25999509, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CDC123 may have a role in novel protein modifications
    Title: The eukaryotic translation initiation regulator CDC123 defines a divergent clade of ATP-grasp enzymes with a predicted role in novel protein modifications.
  2. Data indicate that Cdc123 is a specific assembly factor for eukaryotic translation initiation factor 2 (eIF) subunit alpha (sui2), subunit beta (sui3) and subunit gamma (GCD11), which is indispensable for the onset of protein synthesis.
    Title: Translation initiation requires cell division cycle 123 (Cdc123) to facilitate biogenesis of the eukaryotic initiation factor 2 (eIF2).
  3. the Cdc123-Chf-Gcd11 axis is an essential pathway for nutritional control of START that runs parallel to the Tor-Gcn2-Sui2 system of translational control
    Title: Cdc123 and checkpoint forkhead associated with RING proteins control the cell cycle by controlling eIF2gamma abundance.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within eukaryotic translation initiation factor 2 complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cell proliferation protein CDC123
NP_013316.1
  • Assembly factor for the eIF2 translation initiation factor complex; regulates translational initiation; conserved residues of this ATP-Grasp protein that bind to ATP-Mg2+ in the pombe ortholog are required for complex assembly in budding yeast; interaction with eIF2 subunit Gcd11p facilitates complex assembly and activity; required for the START transition and timely progression through G2; regulated by nutrient availability; human ortholog complements the yeast mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    570776..571858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182102.1 → NP_013316.1  TPA: cell proliferation protein CDC123 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013316.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A7A1A3, D6VYL6, Q05791
    UniProtKB/TrEMBL
    A0A8H4BX77, C8ZDH9, N1NZE9
    Conserved Domains (1) summary
    pfam07065
    Location:27 → 328
    D123
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05791.1

Gene LinkOut

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