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FRM2 type II nitroreductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850332, updated on 13-Apr-2024

Summary

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Gene symbol
FRM2
Gene description
type II nitroreductase
Primary source
SGD:S000000589
Locus tag
YCL026C-A
See related
AllianceGenome:SGD:S000000589
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YCLX08C
Summary
Enables oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor. Involved in cellular response to oxidative stress and negative regulation of fatty acid metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (74704..75285, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Fus1p Neighboring gene putative nitroreductase Neighboring gene amino acid transporter AGP1 Neighboring gene serine/threonine protein kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure of the fungal nitroreductase Frm2 from Saccharomyces cerevisiae. Song HN, et al. Protein Sci, 2015 Jul. PMID 25864423, Free PMC Article
  2. Confirmation of Frm2 as a novel nitroreductase in Saccharomyces cerevisiae. Bang SY, et al. Biochem Biophys Res Commun, 2012 Jul 13. PMID 22687599
  3. The role of two putative nitroreductases, Frm2p and Hbn1p, in the oxidative stress response in Saccharomyces cerevisiae. de Oliveira IM, et al. Yeast, 2010 Feb. PMID 19904831
  4. The S. cerevisiae Yap1 and Yap2 transcription factors share a common cadmium-sensing domain. Azevedo D, et al. FEBS Lett, 2007 Jan 23. PMID 17187783
  5. Identification of a class of Saccharomyces cerevisiae mutants defective in fatty acid repression of gene transcription and analysis of the frm2 gene. McHale MW, et al. Yeast, 1996 Mar 30. PMID 8701605

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The study reports the crystal structure of the fungal nitroreductase Frm2 from Saccharomyces cerevisiae.
    Title: Crystal structure of the fungal nitroreductase Frm2 from Saccharomyces cerevisiae.
  2. this study demonstrates a novel nitroreductase activity of Frm2 and its involvement in the oxidative stress defense system.
    Title: Confirmation of Frm2 as a novel nitroreductase in Saccharomyces cerevisiae.
  3. findings show Frm1p and Hbn1p nitroreductases influence the response to oxidative stress in S. cerevisae by modulating the GSH contents and antioxidant enzymatic activities, such as SOD, CAT & GPx
    Title: The role of two putative nitroreductases, Frm2p and Hbn1p, in the oxidative stress response in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on NAD(P)H IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to oxidative stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
type II nitroreductase
NP_009904.2
  • Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    74704..75285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178713.1 → NP_009904.2  TPA: type II nitroreductase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009904.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQZ0, P37261, Q8NIM8
    UniProtKB/TrEMBL
    A0A6A5Q162, A6ZTG4, B3LU56, B5VET3, C7GSY3, C8Z463, G2WA00, N1P990
    Conserved Domains (1) summary
    COG3560
    Location:2 → 193
    FMR2; Fatty acid repression mutant protein (predicted oxidoreductase) [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37261.2

Gene LinkOut

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