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Cox4i2 cytochrome c oxidase subunit 4i2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84683, updated on 3-Apr-2024

Summary

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Official Symbol
Cox4i2provided by RGD
Official Full Name
cytochrome c oxidase subunit 4i2provided by RGD
Primary source
RGD:69422
See related
Ensembl:ENSRNOG00000007827 AllianceGenome:RGD:69422
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cox4b; CoxIV-2
Summary
Predicted to enable cytochrome-c oxidase activity. Involved in cellular response to hypoxia. Predicted to be located in mitochondrial membrane. Predicted to be part of mitochondrial respiratory chain complex IV. Orthologous to human COX4I2 (cytochrome c oxidase subunit 4I2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 85.6), Heart (RPKM 48.0) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q41
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (161686193..161699605)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (141228443..141239337)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (148234546..148245424)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene histocompatibility minor 13 Neighboring gene MCTS family member 2 Neighboring gene uncharacterized LOC134486187 Neighboring gene uncharacterized LOC134486188 Neighboring gene inhibitor of DNA binding 1 Neighboring gene Bcl2-like 1 Neighboring gene ribosomal protein S2, pseudogene 43 Neighboring gene small nucleolar RNA U109 Neighboring gene TPX2, microtubule nucleation factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Protein phosphorylation and prevention of cytochrome oxidase inhibition by ATP: coupled mechanisms of energy metabolism regulation. Acin-Perez R, et al. Cell Metab, 2011 Jun 8. PMID 21641552, Free PMC Article
  2. Cytochrome c oxidase isoform IV-2 is involved in 3-nitropropionic acid-induced toxicity in striatal astrocytes. Singh S, et al. Glia, 2009 Nov 1. PMID 19306371
  3. HIF-1α regulates COXIV subunits, a potential mechanism of self-protective response to microwave induced mitochondrial damages in neurons. Hao YH, et al. Sci Rep, 2018 Jul 10. PMID 29991768, Free PMC Article
  4. Exocrine pancreatic insufficiency, dyserythropoeitic anemia, and calvarial hyperostosis are caused by a mutation in the COX4I2 gene. Shteyer E, et al. Am J Hum Genet, 2009 Mar. PMID 19268275, Free PMC Article
  5. Undernutrition during suckling in rats elevates plasma adiponectin and its receptor in skeletal muscle regardless of diet composition: a protective effect? Prior LJ, et al. Int J Obes (Lond), 2008 Oct. PMID 18725894

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. microwave induced mitochondrial ROS production activated HIF-1alpha and regulated COXIV-1 expression to restore mitochondria functions. Therefore, HIF-1alpha might be a potential target to impair microwave induced injuries.
    Title: HIF-1α regulates COXIV subunits, a potential mechanism of self-protective response to microwave induced mitochondrial damages in neurons.
  2. mitochondrial energy metabolism regulation by phosphorylation of COXIV-1 is coupled with prevention of COX allosteric inhibition by ATP
    Title: Protein phosphorylation and prevention of cytochrome oxidase inhibition by ATP: coupled mechanisms of energy metabolism regulation.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytochrome-c oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables cytochrome-c oxidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen ISO
Inferred from Sequence Orthology
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome c oxidase subunit 4 isoform 2, mitochondrial
Names
COX IV-2
cytochrome c oxidase subunit IV
cytochrome c oxidase, subunit 4b
cytochrome c oxidase, subunit IVb
NP_445924.1
XP_006235342.1
XP_017447568.1
XP_038961922.1
XP_063140800.1
XP_063140801.1
XP_063140802.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053472.1 → NP_445924.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_445924.1

    Status: PROVISIONAL

    Source sequence(s)
    AF255347
    UniProtKB/Swiss-Prot
    Q91Y94
    UniProtKB/TrEMBL
    A0A8L2UI91, A6KHQ9
    Related
    ENSRNOP00000010418.4, ENSRNOT00000010418.6
    Conserved Domains (1) summary
    pfam02936
    Location:38 → 171
    COX4; Cytochrome c oxidase subunit IV

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    161686193..161699605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284731.1 → XP_063140801.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q91Y94
    UniProtKB/TrEMBL
    A6KHQ9

  2. XM_063284730.1 → XP_063140800.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q91Y94
    UniProtKB/TrEMBL
    A6KHQ9

  3. XM_006235280.4 → XP_006235342.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006235342.1

    UniProtKB/Swiss-Prot
    Q91Y94
    UniProtKB/TrEMBL
    A0A8L2UI91, A6KHQ9
    Conserved Domains (1) summary
    pfam02936
    Location:38 → 171
    COX4; Cytochrome c oxidase subunit IV

  4. XM_017592079.2 → XP_017447568.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZVG3, A6KHQ8
    Related
    ENSRNOP00000082539.1

  5. XM_039105994.2 → XP_038961922.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q91Y94
    UniProtKB/TrEMBL
    A0A8L2UI91, A6KHQ9
    Conserved Domains (1) summary
    pfam02936
    Location:38 → 171
    COX4; Cytochrome c oxidase subunit IV

  6. XM_063284732.1 → XP_063140802.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91Y94.1 GenPept UniProtKB/Swiss-Prot:Q91Y94

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