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FRA3 Endonuclease/exonuclease/phosphatase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 842869, updated on 15-Oct-2023

Summary

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Gene symbol
FRA3
Gene description
Endonuclease/exonuclease/phosphatase family protein
Primary source
Araport:AT1G65580
Locus tag
AT1G65580
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F5I14.11; F5I14_11; FRAGILE FIBER3
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Genomic context

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Location:
chromosome: 1
Exon count:
11
Sequence:
Chromosome: 1; NC_003070.9 (24377263..24384086, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Pectin lyase-like superfamily protein Neighboring gene ncRNA Neighboring gene miscRNA Neighboring gene beta-hexosaminidase 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FRAGILE FIBER3, an Arabidopsis gene encoding a type II inositol polyphosphate 5-phosphatase, is required for secondary wall synthesis and actin organization in fiber cells. Zhong R, et al. Plant Cell, 2004 Dec. PMID 15539468, Free PMC Article
  2. MAPK target networks in Arabidopsis thaliana revealed using functional protein microarrays. Popescu SC, et al. Genes Dev, 2009 Jan 1. PMID 19095804, Free PMC Article
  3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FRA3 type II 5PTase is involved in phosphoinositide metabolism and influences secondary wall synthesis and actin organization.[FRA3] [FRAGILE FIBER3]
    Title: FRAGILE FIBER3, an Arabidopsis gene encoding a type II inositol polyphosphate 5-phosphatase, is required for secondary wall synthesis and actin organization in fiber cells.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001334216.1
NM_105232.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Endonuclease/exonuclease/phosphatase family protein
NP_176736.2
  • FRAGILE FIBER3 (FRA3); FUNCTIONS IN: inositol or phosphatidylinositol phosphatase activity; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Inositol polyphosphate related phosphatase (InterPro:IPR000300), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), Endonuclease/exonuclease/phosphatase (InterPro:IPR005135); BEST Arabidopsis thaliana protein match is: Endonuclease/exonuclease/phosphatase family protein (TAIR:AT2G43900.1); Has 2602 Blast hits to 2499 proteins in 289 species: Archae - 0; Bacteria - 180; Metazoa - 887; Fungi - 607; Plants - 609; Viruses - 0; Other Eukaryotes - 319 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    24377263..24384086 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_105232.3 → NP_176736.2  Endonuclease/exonuclease/phosphatase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_176736.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O04475, Q5MK18, Q84W55, Q9XFT1
    UniProtKB/TrEMBL
    A0A178WER9, A0A5S9WPM5, A0A654EMQ5
    Conserved Domains (4) summary
    cd09074
    Location:538 → 884
    INPP5c; Catalytic domain of inositol polyphosphate 5-phosphatases
    sd00039
    Location:413 → 442
    7WD40; WD40 repeat [structural motif]
    cl27657
    Location:919 → 1043
    Motile_Sperm; MSP (Major sperm protein) domain
    cl29593
    Location:182 → 510
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001334216.1 → NP_001321558.1  Endonuclease/exonuclease/phosphatase family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AR99
    Conserved Domains (4) summary
    cd09074
    Location:272 → 618
    INPP5c; Catalytic domain of inositol polyphosphate 5-phosphatases
    sd00039
    Location:147 → 176
    7WD40; WD40 repeat [structural motif]
    cl27657
    Location:653 → 777
    Motile_Sperm; MSP (Major sperm protein) domain
    cl29593
    Location:155 → 244
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q84W55.2

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