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BCAR3 BCAR3 adaptor protein, NSP family member [ Homo sapiens (human) ]

Gene ID: 8412, updated on 3-Apr-2024

Summary

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Official Symbol
BCAR3provided by HGNC
Official Full Name
BCAR3 adaptor protein, NSP family memberprovided by HGNC
Primary source
HGNC:HGNC:973
See related
Ensembl:ENSG00000137936 MIM:604704; AllianceGenome:HGNC:973
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIG7; NSP2; AND-34; SH2D3B
Summary
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Expression
Ubiquitous expression in fat (RPKM 13.8), placenta (RPKM 6.5) and 23 other tissues See more
Orthologs
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Genomic context

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See BCAR3 in Genome Data Viewer
Location:
1p22.1
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (93561741..93848151, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (93407475..93693898, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (94027298..94312775, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene formin binding protein 1 like Neighboring gene RNA, 5S ribosomal pseudogene 53 Neighboring gene tRNA-Cys (anticodon GCA) 7-1 Neighboring gene Sharpr-MPRA regulatory region 13550 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:94018571-94019099 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:94038039-94039036 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:94050266-94050778 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:94054146-94054690 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:94054691-94055235 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:94057721-94058221 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:94075253-94075816 Neighboring gene BCAR3 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:94079051-94079704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:94079705-94080357 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:94081011-94081663 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:94082971-94083623 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:94101848-94102406 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:94102407-94102965 Neighboring gene Sharpr-MPRA regulatory region 755 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:94104972-94105607 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1333 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:94109607-94110328 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:94127441-94128640 Neighboring gene Sharpr-MPRA regulatory region 8830 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1084 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:94158555-94159754 Neighboring gene uncharacterized LOC102723480 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:94166702-94167901 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1337 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1085 Neighboring gene Sharpr-MPRA regulatory region 5000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1341 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:94203124-94204323 Neighboring gene Sharpr-MPRA regulatory region 10321 Neighboring gene MPRA-validated peak324 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:94261424-94262012 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:94279629-94280169 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:94298677-94299315 Neighboring gene MPRA-validated peak325 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1087 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:94312484-94313274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1343 Neighboring gene tRNA-Arg (anticodon TCT) 1-1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:94344769-94345584 Neighboring gene microRNA 760 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:94356477-94356625 Neighboring gene deoxynucleotidyltransferase terminal interacting protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1089 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1090 Neighboring gene glutamate-cysteine ligase modifier subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Silencing of Mig-7 expression inhibits in-vitro invasiveness and vasculogenic mimicry of human glioma U87 Cells. Pan Z, et al. Neuroreport, 2019 Dec 10. PMID 31688418
  2. [Mig-7 gene silencing inhibits vasculogenic mimicry formation and invasion of glioma U251 cells in vitro by suppressing MEK/ERK signaling]. Wang F, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2019 May 30. PMID 31140421, Free PMC Article
  3. Prediction and prognostic significance of BCAR3 expression in patients with multiple myeloma. Zhang W, et al. J Transl Med, 2018 Dec 18. PMID 30563570, Free PMC Article
  4. Migration-inducing gene-7 independently predicts poor prognosis of human osteosarcoma and is associated with vasculogenic mimicry. Ren K, et al. Exp Cell Res, 2018 Aug 1. PMID 29750896
  5. MIG7 is involved in vasculogenic mimicry formation rendering invasion and metastasis in hepatocellular carcinoma. Qu B, et al. Oncol Rep, 2018 Feb. PMID 29251318

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircBCAR3 sponges miR-27a-3p and mediates ferroptosis in human B-prolymphocytic leukaemia cells via SLC7A11.
    Title: CircBCAR3 sponges miR-27a-3p and mediates ferroptosis in human B-prolymphocytic leukaemia cells via SLC7A11.
  2. Comprehensive immunohistochemical analysis of RET, BCAR1, and BCAR3 expression in patients with Luminal A and B breast cancer subtypes.
    Title: Comprehensive immunohistochemical analysis of RET, BCAR1, and BCAR3 expression in patients with Luminal A and B breast cancer subtypes.
  3. A Cas-BCAR3 co-regulatory circuit controls lamellipodia dynamics.
    Title: A Cas-BCAR3 co-regulatory circuit controls lamellipodia dynamics.
  4. MIG-7 mRNA expression may serve as an additional molecular marker of vasculogenic mimicry in ovarian malignancies.
    Title: Mig-7 expression and vasculogenic mimicry in malignant ovarian tumors.
  5. Study provides evidence that MIG7 expression in hepatocellular carcinoma (HCC) tissue is correlated positively with vasculogenic mimicry (VM) formation and MIG7 expression in different HCC cell lines is coincident with their VM formation, invasion and metastasis.
    Title: MIG7 is involved in vasculogenic mimicry formation rendering invasion and metastasis in hepatocellular carcinoma.
  6. this study indicates that the expression of Mig-7 in gliomas is positively correlated with vasculogenic mimicry formation and is related to the glioma pathological grade
    Title: Silencing of Mig-7 expression inhibits in-vitro invasiveness and vasculogenic mimicry of human glioma U87 Cells.
  7. MIG-7 serves as an independent unfavorable prognostic indicator in osteosarcoma patients and MIG-7 is an important mediator of osteosarcoma Vascular Mimicry formation.
    Title: Migration-inducing gene-7 independently predicts poor prognosis of human osteosarcoma and is associated with vasculogenic mimicry.
  8. The high expressions of Mig-7 and MMP-2 in gastric carcinoma tissues may have a synergistic promoting effect on VM formation. VM is closely associated with the invasion, metastasis and poor prognosis of gastric carcinoma.
    Title: [Expressions and clinical significance of vasculogenic mimicry and related protein Mig-7 and MMP-2 in gastric carcinoma].
  9. MIG7 expression in hepatocellular carcinoma tissue is high and correlated positively with vasculogenic mimicry formation, invasion and metastasis.
    Title: [MIG7 Regulates the Vasculogenic Mimicry Formation in Hepatocellular Carcinoma then Effects the Metastasis Potential of HCC].
  10. Silencing of Mig-7 gene inhibits vasculogenic mimicry formation and invasion of U251 cells possibly by suppressing MEK/ERK signaling, suggesting the important role of Mig-7 gene in vasculogenic mimicry formation and invasion of human glioma cells
    Title: [Mig-7 gene silencing inhibits vasculogenic mimicry formation and invasion of glioma U251 cells in vitro by suppressing MEK/ERK signaling].
Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0554

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphotyrosine residue binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endothelin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lens morphogenesis in camera-type eye IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to xenobiotic stimulus TAS
Traceable Author Statement
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
breast cancer anti-estrogen resistance protein 3
Names
BCAR3, NSP family adaptor protein
SH2 domain-containing protein 3B
breast cancer anti-estrogen resistance 3
breast cancer antiestrogen resistance 3 protein
dJ1033H22.2 (breast cancer anti-estrogen resistance 3)
epididymis secretory sperm binding protein
mig-7
migration inducting gene-7
novel SH2-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261408.2 → NP_001248337.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001248337.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AL049796, AL109613, BC028477, BQ015705
    Consensus CDS
    CCDS745.1
    UniProtKB/Swiss-Prot
    D3DT43, O75815, Q5TEW3, Q6UW40, Q9BR50
    UniProtKB/TrEMBL
    A0A384MTS3, B3KP06
    Related
    ENSP00000359264.1, ENST00000370244.5
    Conserved Domains (2) summary
    cd10337
    Location:147 → 282
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    smart00147
    Location:544 → 819
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

  2. NM_001261409.1 → NP_001248338.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001248338.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AK027785, AK055442, BQ015705, DA745974
    Consensus CDS
    CCDS745.1
    UniProtKB/Swiss-Prot
    D3DT43, O75815, Q5TEW3, Q6UW40, Q9BR50
    UniProtKB/TrEMBL
    A0A384MTS3, B3KP06
    Related
    ENSP00000359263.1, ENST00000370243.1
    Conserved Domains (2) summary
    cd10337
    Location:147 → 282
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    smart00147
    Location:544 → 819
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

  3. NM_001261410.2 → NP_001248339.1  breast cancer anti-estrogen resistance protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001248339.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL109613, AL833121, BQ015705
    Consensus CDS
    CCDS58010.1
    UniProtKB/TrEMBL
    B3KP06
    Related
    ENSP00000359267.3, ENST00000370247.7
    Conserved Domains (2) summary
    cd10337
    Location:56 → 191
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    smart00147
    Location:453 → 728
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

  4. NM_001308251.1 → NP_001295180.1  breast cancer anti-estrogen resistance protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001295180.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a significantly shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK310970, AW470748, AY358996
    Consensus CDS
    CCDS76181.1
    UniProtKB/TrEMBL
    B4DWK2
    Related
    ENSP00000441343.1, ENST00000539242.5
    Conserved Domains (1) summary
    smart00147
    Location:220 → 495
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

  5. NM_001412043.1 → NP_001398972.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL109613, AL359820
    UniProtKB/Swiss-Prot
    D3DT43, O75815, Q5TEW3, Q6UW40, Q9BR50
    UniProtKB/TrEMBL
    A0A384MTS3

  6. NM_001412044.1 → NP_001398973.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL109613, AL359820
    UniProtKB/Swiss-Prot
    D3DT43, O75815, Q5TEW3, Q6UW40, Q9BR50
    UniProtKB/TrEMBL
    A0A384MTS3

  7. NM_001412045.1 → NP_001398974.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL109613, AL359820
    UniProtKB/Swiss-Prot
    D3DT43, O75815, Q5TEW3, Q6UW40, Q9BR50
    UniProtKB/TrEMBL
    A0A384MTS3

  8. NM_001412046.1 → NP_001398975.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL109613, AL359820
    UniProtKB/Swiss-Prot
    D3DT43, O75815, Q5TEW3, Q6UW40, Q9BR50
    UniProtKB/TrEMBL
    A0A384MTS3

  9. NM_001412048.1 → NP_001398977.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL109613, AL359820
    UniProtKB/Swiss-Prot
    D3DT43, O75815, Q5TEW3, Q6UW40, Q9BR50
    UniProtKB/TrEMBL
    A0A384MTS3

  10. NM_001412049.1 → NP_001398978.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL109613, AL359820
    UniProtKB/Swiss-Prot
    D3DT43, O75815, Q5TEW3, Q6UW40, Q9BR50
    UniProtKB/TrEMBL
    A0A384MTS3

  11. NM_001412050.1 → NP_001398979.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820
    UniProtKB/Swiss-Prot
    D3DT43, O75815, Q5TEW3, Q6UW40, Q9BR50
    UniProtKB/TrEMBL
    A0A384MTS3

  12. NM_001412051.1 → NP_001398980.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820
    UniProtKB/Swiss-Prot
    D3DT43, O75815, Q5TEW3, Q6UW40, Q9BR50
    UniProtKB/TrEMBL
    A0A384MTS3

  13. NM_001412052.1 → NP_001398981.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820
    UniProtKB/Swiss-Prot
    D3DT43, O75815, Q5TEW3, Q6UW40, Q9BR50
    UniProtKB/TrEMBL
    A0A384MTS3

  14. NM_001412054.1 → NP_001398983.1  breast cancer anti-estrogen resistance protein 3 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL109613, AL359820

  15. NM_001412055.1 → NP_001398984.1  breast cancer anti-estrogen resistance protein 3 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL109613, AL359820

  16. NM_001412056.1 → NP_001398985.1  breast cancer anti-estrogen resistance protein 3 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL109613, AL359820

  17. NM_001412057.1 → NP_001398986.1  breast cancer anti-estrogen resistance protein 3 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820

  18. NM_001412058.1 → NP_001398987.1  breast cancer anti-estrogen resistance protein 3 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820
    UniProtKB/TrEMBL
    B3KNL6

  19. NM_001412059.1 → NP_001398988.1  breast cancer anti-estrogen resistance protein 3 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820

  20. NM_001412060.1 → NP_001398989.1  breast cancer anti-estrogen resistance protein 3 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820

  21. NM_001412061.1 → NP_001398990.1  breast cancer anti-estrogen resistance protein 3 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820

  22. NM_001412062.1 → NP_001398991.1  breast cancer anti-estrogen resistance protein 3 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820

  23. NM_001412064.1 → NP_001398993.1  breast cancer anti-estrogen resistance protein 3 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820

  24. NM_001412065.1 → NP_001398994.1  breast cancer anti-estrogen resistance protein 3 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820

  25. NM_001412066.1 → NP_001398995.1  breast cancer anti-estrogen resistance protein 3 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820

  26. NM_001412067.1 → NP_001398996.1  breast cancer anti-estrogen resistance protein 3 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820

  27. NM_001412072.1 → NP_001399001.1  breast cancer anti-estrogen resistance protein 3 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820

  28. NM_001412073.1 → NP_001399002.1  breast cancer anti-estrogen resistance protein 3 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820

  29. NM_001412074.1 → NP_001399003.1  breast cancer anti-estrogen resistance protein 3 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL109613

  30. NM_001412075.1 → NP_001399004.1  breast cancer anti-estrogen resistance protein 3 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL109613

  31. NM_001412076.1 → NP_001399005.1  breast cancer anti-estrogen resistance protein 3 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL109613

  32. NM_001412077.1 → NP_001399006.1  breast cancer anti-estrogen resistance protein 3 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL109613
    UniProtKB/TrEMBL
    B3KNL6

  33. NM_003567.4 → NP_003558.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    See identical proteins and their annotated locations for NP_003558.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AF124250, AL109613, BQ015705, CN337133
    Consensus CDS
    CCDS745.1
    UniProtKB/Swiss-Prot
    D3DT43, O75815, Q5TEW3, Q6UW40, Q9BR50
    UniProtKB/TrEMBL
    A0A384MTS3, B3KP06
    Related
    ENSP00000260502.6, ENST00000260502.11
    Conserved Domains (2) summary
    cd10337
    Location:147 → 282
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    smart00147
    Location:544 → 819
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

RNA

  1. NR_148965.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL512488
    Related
    ENST00000433544.1

  2. NR_171551.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL512488

  3. NR_178002.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796

  4. NR_178003.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL512488

  5. NR_178005.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796

  6. NR_178006.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL512488

  7. NR_178007.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796

  8. NR_178009.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796

  9. NR_178010.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL512488

  10. NR_178011.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL512488

  11. NR_178013.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL359820

  12. NR_178014.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796

  13. NR_178015.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796

  14. NR_178016.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL359820

  15. NR_178017.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL512488

  16. NR_178018.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL512488

  17. NR_178021.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL512488

  18. NR_178022.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL512488

  19. NR_178023.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820

  20. NR_178024.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    93561741..93848151 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    93407475..93693898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75815.1 GenPept UniProtKB/Swiss-Prot:O75815

Gene LinkOut

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