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SBH2 sphingoid base hydroxylase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837990, updated on 15-Feb-2024

Summary

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Gene symbol
SBH2
Gene description
sphingoid base hydroxylase 2
Primary source
Araport:AT1G14290
Locus tag
AT1G14290
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtSBH2; F14L17.5; F14L17_5; sphingoid base hydroxylase 2
Summary
Encodes one of the two redundant sphingoid base hydroxylases (SBH). Involved in sphingolipid trihydroxy long-chain base (4-hydroxysphinganine) biosynthesis. Double mutants of SBHs were dwarfed and not able to progress from vegetative to reproductive growth.
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Genomic context

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Location:
chromosome: 1
Exon count:
2
Sequence:
Chromosome: 1; NC_003070.9 (4880030..4882265, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene RING/FYVE/PHD zinc finger superfamily protein Neighboring gene CAAX amino terminal protease family protein Neighboring gene phytochrome kinase substrate 2 Neighboring gene ARM repeat superfamily protein Neighboring gene Haloacid dehalogenase-like hydrolase (HAD) superfamily protein Neighboring gene F-box and associated interaction domains-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sphingolipid long-chain base hydroxylation is important for growth and regulation of sphingolipid content and composition in Arabidopsis. Chen M, et al. Plant Cell, 2008 Jul. PMID 18612100, Free PMC Article
  2. Functional characterization of sphingolipid C4-hydroxylase genes from Arabidopsis thaliana. Sperling P, et al. FEBS Lett, 2001 Apr 6. PMID 11297741
  3. Systematic analysis of protein subcellular localization and interaction using high-throughput transient transformation of Arabidopsis seedlings. Marion J, et al. Plant J, 2008 Oct. PMID 18643979
  4. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
  5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001332110.1
NM_101295.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables sphingolipid C4-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables sphingosine hydroxylase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within photomorphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sphingoid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sphingoid base hydroxylase 2
NP_563944.1
  • sphingoid base hydroxylase 2 (SBH2); CONTAINS InterPro DOMAIN/s: Fatty acid hydroxylase (InterPro:IPR006694); BEST Arabidopsis thaliana protein match is: sphingoid base hydroxylase 1 (TAIR:AT1G69640.1); Has 2314 Blast hits to 2272 proteins in 379 species: Archae - 0; Bacteria - 367; Metazoa - 413; Fungi - 680; Plants - 393; Viruses - 3; Other Eukaryotes - 458 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    4880030..4882265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_101295.5 → NP_563944.1  sphingoid base hydroxylase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_563944.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9AST3, Q9M9T3
    UniProtKB/TrEMBL
    A0A178WPE2, A0A5S9UDN2
    Conserved Domains (1) summary
    pfam04116
    Location:98 → 234
    FA_hydroxylase; Fatty acid hydroxylase superfamily

  2. NM_001332110.1 → NP_001320936.1  sphingoid base hydroxylase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8APD5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9AST3.1

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