AT5G38710 Methylenetetrahydrofolate reductase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: AT5G38710
Gene description: Methylenetetrahydrofolate reductase family protein
Primary source: Araport:AT5G38710
Locus tag: AT5G38710
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: MKD10.10; MKD10_10
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Genomic context

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Location:: chromosome: 5

Exon count:: 4

Sequence:: Chromosome: 5; NC_003076.8 (15501126..15504269)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ProDH1 and ProDH2 are both necessary to achieve maximum resistance against Pseudomonas syringae pv. tomato AvrRpm1 and B. cinerea.[ProDH2]
Title: Differential control and function of Arabidopsis ProDH1 and ProDH2 genes on infection with biotrophic and necrotrophic pathogens.
ProDH2 may play an important role in Proline homeostasis in the vasculature, especially under stress conditions that promote Proline accumulation. [ProDH2]
Title: Non-redundant functions of two proline dehydrogenase isoforms in Arabidopsis.

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Pathways from PubChem

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General gene information

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Homology

Orthologs from OrthoDB

NM_001344262.1

Supported by ESTs:

NM_123232.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables proline dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables proline dehydrogenase activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in proline catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proline catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proline catabolic process to glutamate	IEA Inferred from Electronic Annotation more info
involved_in response to osmotic stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to water deprivation	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Methylenetetrahydrofolate reductase family protein

NP_198687.1

Methylenetetrahydrofolate reductase family protein; FUNCTIONS IN: proline dehydrogenase activity; INVOLVED IN: oxidation reduction, proline catabolic process, glutamate biosynthetic process; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Proline dehydrogenase (InterPro:IPR002872), Proline oxidase (InterPro:IPR015659); BEST Arabidopsis thaliana protein match is: Methylenetetrahydrofolate reductase family protein (TAIR:AT3G30775.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

15501126..15504269

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_123232.3 → NP_198687.1 Methylenetetrahydrofolate reductase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_198687.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6NKX1, Q9FKR5

UniProtKB/TrEMBL

A0A178UQV1

Conserved Domains (2) summary

PLN02681
Location:19 → 476

PLN02681; proline dehydrogenase

pfam01619
Location:226 → 456

Pro_dh; Proline dehydrogenase
NM_001344262.1 → NP_001330954.1 Methylenetetrahydrofolate reductase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UQV1, A0A1P8BCG0