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PIMT1 protein-l-isoaspartate methyltransferase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 823991, updated on 7-Sep-2023

Summary

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Gene symbol
PIMT1
Gene description
protein-l-isoaspartate methyltransferase 1
Primary source
Araport:AT3G48330
Locus tag
AT3G48330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
Arabidopsis thaliana protein-l-isoaspartate methyltransferase 1; ATPIMT1; protein-l-isoaspartate methyltransferase 1
Summary
Encodes protein-L-isoaspartate methyltransferase. Important for maintaining viability as the seed ages. Involved in germination.
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Genomic context

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Location:
chromosome: 3
Exon count:
5
Sequence:
Chromosome: 3; NC_003074.8 (17892738..17894162, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 71, subfamily A, polypeptide 22 Neighboring gene cytochrome P450, family 71, subfamily A, polypeptide 21 Neighboring gene ncRNA Neighboring gene tRNA-Thr Neighboring gene Cysteine proteinases superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein repair L-isoaspartyl methyltransferase 1 is involved in both seed longevity and germination vigor in Arabidopsis. Ogé L, et al. Plant Cell, 2008 Nov. PMID 19011119, Free PMC Article
  2. Arabidopsis Protein Repair L-Isoaspartyl Methyltransferases: Predominant Activities at Lethal Temperatures. Villa ST, et al. Physiol Plant, 2006 Dec. PMID 21076691, Free PMC Article
  3. Substrates of the Arabidopsis thaliana protein isoaspartyl methyltransferase 1 identified using phage display and biopanning. Chen T, et al. J Biol Chem, 2010 Nov 26. PMID 20870712, Free PMC Article
  4. A second protein L-isoaspartyl methyltransferase gene in Arabidopsis produces two transcripts whose products are sequestered in the nucleus. Xu Q, et al. Plant Physiol, 2004 Sep. PMID 15347786, Free PMC Article
  5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 17 PIMT target proteins all contain at least one susceptible Asp or Asn residue.
    Title: Substrates of the Arabidopsis thaliana protein isoaspartyl methyltransferase 1 identified using phage display and biopanning.
  2. PIMT1 overaccumulation reduced the accumulation of L-isoaspartyl residues in seed proteins and increased both seed longevity and germination vigor.
    Title: Protein repair L-isoaspartyl methyltransferase 1 is involved in both seed longevity and germination vigor in Arabidopsis.
Submit: New GeneRIF Correction

General gene information

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Homology

NM_001339361.1
NM_001339362.1
NM_148859.4
NM_180682.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein repair TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within response to abscisic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to salt stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within seed germination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
protein-l-isoaspartate methyltransferase 1
NP_680112.2
  • protein-l-isoaspartate methyltransferase 1 (PIMT1); FUNCTIONS IN: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; INVOLVED IN: protein modification process, response to salt stress, aging, response to abscisic acid stimulus, seed germination; LOCATED IN: cellular_component unknown; EXPRESSED IN: seedling, seed; EXPRESSED DURING: dry seed stage; CONTAINS InterPro DOMAIN/s: Protein-L-isoaspartate(D-aspartate) O-methyltransferase (InterPro:IPR000682); BEST Arabidopsis thaliana protein match is: protein-l-isoaspartate methyltransferase 2 (TAIR:AT5G50240.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_851013.2
  • protein-l-isoaspartate methyltransferase 1 (PIMT1); FUNCTIONS IN: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; INVOLVED IN: protein modification process, response to salt stress, aging, response to abscisic acid stimulus, seed germination; LOCATED IN: cellular_component unknown; EXPRESSED IN: seedling, seed; EXPRESSED DURING: dry seed stage; CONTAINS InterPro DOMAIN/s: Protein-L-isoaspartate(D-aspartate) O-methyltransferase (InterPro:IPR000682); BEST Arabidopsis thaliana protein match is: protein-l-isoaspartate methyltransferase 2 (TAIR:AT5G50240.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    17892738..17894162 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_148859.4 → NP_680112.2  protein-l-isoaspartate methyltransferase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_680112.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0JQ02, Q42539, Q9STL3
    UniProtKB/TrEMBL
    A0A178VNY7
    Conserved Domains (2) summary
    pfam01135
    Location:11 → 220
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    cl17173
    Location:12 → 225
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. NM_180682.4 → NP_851013.2  protein-l-isoaspartate methyltransferase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_851013.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0JQ02, Q42539, Q9STL3
    UniProtKB/TrEMBL
    A0A178VNY7
    Conserved Domains (2) summary
    pfam01135
    Location:11 → 220
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    cl17173
    Location:12 → 225
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. NM_001339361.1 → NP_001326364.1  protein-l-isoaspartate methyltransferase 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VNY7, A0A1I9LP19

  4. NM_001339362.1 → NP_001326363.1  protein-l-isoaspartate methyltransferase 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I9LP18, A0A654FDX5
    Conserved Domains (1) summary
    pfam01135
    Location:64 → 273
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q42539.3

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