AUX1 Transmembrane amino acid transporter family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: AUX1
Gene description: Transmembrane amino acid transporter family protein
Primary source: Araport:AT2G38120
Locus tag: AT2G38120
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtAUX1; AUXIN RESISTANT 1; F16M14.5; F16M14_5; MAP1; MODIFIER OF ARF7/NPH4 PHENOTYPES 1; PIR1; WAV5; WAVY ROOTS 5
Summary: Encodes an auxin influx transporter. AUX1 resides at the apical plasma membrane of protophloem cells and at highly dynamic subpopulations of Golgi apparatus and endosomes in all cell types. AUX1 action in the lateral root cap and/or epidermal cells influences lateral root initiation and positioning. Shoot supplied ammonium targets AUX1 and inhibits lateral root emergence.
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Genomic context

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Location:: chromosome: 2

Exon count:: 9

Sequence:: Chromosome: 2; NC_003071.7 (15972876..15977180)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Auxin resistant 1 gene (AUX1) mediates auxin effect on Arabidopsis thaliana callus growth by regulating its content and distribution pattern.
Title: Auxin resistant 1 gene (AUX1) mediates auxin effect on Arabidopsis thaliana callus growth by regulating its content and distribution pattern.
Mechanistic insight into the role of AUXIN RESISTANCE4 in trafficking of AUXIN1 and LIKE AUX1-2.
Title: Mechanistic insight into the role of AUXIN RESISTANCE4 in trafficking of AUXIN1 and LIKE AUX1-2.
AUX1, PIN3, and TAA1 collectively maintain fertility in Arabidopsis.
Title: AUX1, PIN3, and TAA1 collectively maintain fertility in Arabidopsis.
Auxin-induced actin cytoskeleton rearrangements require AUX1.
Title: Auxin-induced actin cytoskeleton rearrangements require AUX1.
Molecular determinants of potassium stimulation of indole-3-acetic acid transport mediated by the Arabidopsis Importer AUX1 investigated in a heterologous yeast system have been reported.
Title: Potassium Stimulation of IAA Transport Mediated by the Arabidopsis Importer AUX1 Investigated in a Heterologous Yeast System.
The structure activity relationship data were analysed using molecular field analyses to create a pharmacophoric atlas of AUX1 substrates.
Title: Auxin molecular field maps define AUX1 selectivity: many auxin herbicides are not substrates.
ethylene mediates hexavalent form of chromium-induced inhibition of primary root elongation by increasing auxin accumulation and polar transport by stimulating the expression of AUX1.
Title: Ethylene mediates dichromate-induced inhibition of primary root growth by altering AUX1 expression and auxin accumulation in Arabidopsis thaliana.
These findings support AUX1 plays a role in root gravitropism upstream of PIN2.
Title: AUX1 acts upstream of PIN2 in regulating root gravitropism.
AUX1-mediated root hair auxin influx governs SCF-type calcium signaling.
Title: AUX1-mediated root hair auxin influx governs SCF(TIR1/AFB)-type Ca(2+) signaling.
RopGEF1 is critical for AUX1 localization.
Title: RopGEF1 Plays a Critical Role in Polar Auxin Transport in Early Development.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001336689.1

Supported by ESTs:

NM_129368.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables amino acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables auxin binding	IDA Inferred from Direct Assay more info	PubMed
enables auxin influx transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within amino acid transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within auxin polar transport	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within establishment of planar polarity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lateral root formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lateral root formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive gravitropism	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to auxin	NAS Non-traceable Author Statement more info
acts_upstream_of_or_within response to ethylene	NAS Non-traceable Author Statement more info
acts_upstream_of_or_within response to nematode	HEP more info	PubMed
acts_upstream_of_or_within root cap development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within root hair cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somatic embryogenesis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within somatic embryogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Transmembrane amino acid transporter family protein

NP_565882.1

AUXIN RESISTANT 1 (AUX1); CONTAINS InterPro DOMAIN/s: Amino acid transporter, transmembrane (InterPro:IPR013057); BEST Arabidopsis thaliana protein match is: like AUXIN RESISTANT 1 (TAIR:AT5G01240.1); Has 1256 Blast hits to 1251 proteins in 143 species: Archae - 0; Bacteria - 0; Metazoa - 116; Fungi - 283; Plants - 825; Viruses - 0; Other Eukaryotes - 32 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

15972876..15977180

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_129368.3 → NP_565882.1 Transmembrane amino acid transporter family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_565882.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q96247

UniProtKB/TrEMBL

A0A178VZ45, A0A5S9X514

Conserved Domains (1) summary

PLN03074
Location:2 → 469

PLN03074; auxin influx permease; Provisional
NM_001336689.1 → NP_001324970.1 Transmembrane amino acid transporter family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B1Q8