U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Emp3 epithelial membrane protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81505, updated on 30-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Emp3provided by RGD
Official Full Name
epithelial membrane protein 3provided by RGD
Primary source
RGD:621094
See related
Ensembl:ENSRNOG00000021104 AllianceGenome:RGD:621094
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in bleb assembly and cell death. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human EMP3 (epithelial membrane protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 310.2), Lung (RPKM 203.6) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1q22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (105525086..105528370, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96388651..96391946, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101900731..101903948, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene synaptogyrin 4 Neighboring gene transmembrane protein 143 Neighboring gene outer dynein arm docking complex subunit 1 Neighboring gene ATP binding cassette subfamily C member 6

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genetic dissection of dome formation in a mammary cell line: identification of two genes with opposing action. Zucchi I, et al. Proc Natl Acad Sci U S A, 1999 Nov 23. PMID 10570147, Free PMC Article
  2. Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus. Wilson HL, et al. J Biol Chem, 2002 Sep 13. PMID 12107182
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC108667

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in bleb assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in bleb assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
epithelial membrane protein 3
Names
EMP-3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030847.2 → NP_110474.1  epithelial membrane protein 3

    See identical proteins and their annotated locations for NP_110474.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q9QYW5
    UniProtKB/TrEMBL
    A6JBA1
    Related
    ENSRNOP00000028656.2, ENSRNOT00000028656.5
    Conserved Domains (1) summary
    cl21598
    Location:12 → 156
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    105525086..105528370 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008759418.3 → XP_008757640.1  epithelial membrane protein 3 isoform X1

    See identical proteins and their annotated locations for XP_008757640.1

    UniProtKB/Swiss-Prot
    Q9QYW5
    UniProtKB/TrEMBL
    A6JBA1
    Conserved Domains (1) summary
    cl21598
    Location:12 → 156
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  2. XM_006229158.5 → XP_006229220.1  epithelial membrane protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006229220.1

    UniProtKB/Swiss-Prot
    Q9QYW5
    UniProtKB/TrEMBL
    A6JBA1
    Conserved Domains (1) summary
    cl21598
    Location:12 → 156
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  3. XM_039091912.2 → XP_038947840.1  epithelial membrane protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9QYW5
    UniProtKB/TrEMBL
    A6JBA1
    Conserved Domains (1) summary
    cl21598
    Location:12 → 156
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QYW5.1 GenPept UniProtKB/Swiss-Prot:Q9QYW5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous