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Fcrl2 Fc receptor like 2 [ Mus musculus (house mouse) ]

Gene ID: 80891, updated on 3-Apr-2024

Summary

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Official Symbol
Fcrl2provided by MGI
Official Full Name
Fc receptor like 2provided by MGI
Primary source
MGI:MGI:1933397
See related
Ensembl:ENSMUSG00000015852 AllianceGenome:MGI:1933397
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IgSR; Msr2; Fcrh2; Fcrls; IFGP2; MMAN-g; FcRH2sc; moFcRH2sc; 9330158F12; 2810439C17Rik
Summary
Predicted to enable protein phosphatase binding activity; signaling adaptor activity; and transmembrane signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway. Predicted to be located in cell surface. Predicted to be integral component of plasma membrane. Orthologous to human FCRL2 (Fc receptor like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in mammary gland adult (RPKM 8.9), subcutaneous fat pad adult (RPKM 7.7) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F1; 3 38.19 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87158318..87171046, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (87250736..87263765, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene kirre like nephrin family adhesion molecule 1 Neighboring gene STARR-seq mESC enhancer starr_08147 Neighboring gene VISTA enhancer mm1616 Neighboring gene STARR-seq mESC enhancer starr_08154 Neighboring gene predicted gene 10705 Neighboring gene predicted gene, 31879 Neighboring gene STARR-positive B cell enhancer mm9_chr3:87127693-87127994 Neighboring gene predicted gene, 31940 Neighboring gene CD5 antigen-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Class A scavenger receptor-1/2 facilitates the uptake of bovine milk exosomes in murine bone marrow-derived macrophages and C57BL/6J mice. Khanam A, et al. Am J Physiol Cell Physiol, 2021 Sep 1. PMID 34378992, Free PMC Article
  2. Differential B cell expression of mouse Fc receptor homologs. Davis RS, et al. Int Immunol, 2004 Sep. PMID 15302849
  3. New nomenclature for Fc receptor-like molecules. Maltais LJ, et al. Nat Immunol, 2006 May. PMID 16622424
  4. A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1. Guselnikov SV, et al. Immunogenetics, 2002 May. PMID 12037601
  5. Phosphatidylinositol 3-kinase, phosphoinositide-specific phospholipase-Cgamma and protein kinase-C signal myelin phagocytosis mediated by complement receptor-3 alone and combined with scavenger receptor-AI/II in macrophages. Makranz C, et al. Neurobiol Dis, 2004 Mar. PMID 15006698

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Class A scavenger receptor-1/2 facilitates the uptake of bovine milk exosomes in murine bone marrow-derived macrophages and C57BL/6J mice.
    Title: Class A scavenger receptor-1/2 facilitates the uptake of bovine milk exosomes in murine bone marrow-derived macrophages and C57BL/6J mice.
  2. SR-A and CD36 are responsible for the preponderance of modified LDL uptake in macrophages and that other scavenger receptors do not compensate for their absence
    Title: Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (7) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Fc receptor-like protein 2
Names
Fc receptor-like S, scavenger receptor
immunoglobulin scavenger receptor
macrophage scavenger receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419220.1 → NP_001406149.1  Fc receptor-like protein 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC091682
    UniProtKB/TrEMBL
    Q9EQY5

  2. NM_030707.4 → NP_109632.2  Fc receptor-like protein 2 precursor

    See identical proteins and their annotated locations for NP_109632.2

    Status: VALIDATED

    Source sequence(s)
    AC091682
    Consensus CDS
    CCDS38471.1
    UniProtKB/TrEMBL
    Q91YK7, Q9EQY5
    Related
    ENSMUSP00000088508.5, ENSMUST00000090986.11
    Conserved Domains (5) summary
    smart00202
    Location:402 → 502
    SR; Scavenger receptor Cys-rich
    smart00409
    Location:316 → 395
    IG; Immunoglobulin
    smart00410
    Location:224 → 302
    IG_like; Immunoglobulin like
    pfam13927
    Location:112 → 181
    Ig_3; Immunoglobulin domain
    cl11960
    Location:19 → 85
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    87158318..87171046 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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