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hibch 3-hydroxyisobutyryl-CoA hydrolase [ Danio rerio (zebrafish) ]

Gene ID: 798364, updated on 27-Mar-2024

Summary

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Official Symbol
hibchprovided by ZNC
Official Full Name
3-hydroxyisobutyryl-CoA hydrolaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050327-29
See related
Ensembl:ENSDARG00000054867 AllianceGenome:ZFIN:ZDB-GENE-050327-29
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:110824
Summary
Predicted to enable 3-hydroxyisobutyryl-CoA hydrolase activity. Predicted to be involved in valine catabolic process. Predicted to act upstream of or within branched-chain amino acid catabolic process. Predicted to be active in mitochondrion. Orthologous to human HIBCH (3-hydroxyisobutyryl-CoA hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (40874208..40924919)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (41072421..41123132)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family A (ABC1), member 12 Neighboring gene protein O-fucosyltransferase 2 Neighboring gene myostatin b Neighboring gene PMS1 homolog 1, mismatch repair system component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The pro-inflammatory signalling regulator Stat4 promotes vasculogenesis of great vessels derived from endothelial precursors. Meng ZZ, et al. Nat Commun, 2017 Mar 3. PMID 28256502, Free PMC Article
  2. High-Resolution Proteomic Profiling Shows Sexual Dimorphism in Zebrafish Heart-Associated Proteins. Niksirat H, et al. J Proteome Res, 2021 Aug 6. PMID 34185526
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC110824

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 3-hydroxyisobutyryl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-hydroxyisobutyryl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within branched-chain amino acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in valine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in valine catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
Names
3-hydroxyisobutyryl-Coenzyme A hydrolase
HIB-CoA hydrolase
HIBYL-CoA-H
NP_001014338.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014316.1 → NP_001014338.1  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

    See identical proteins and their annotated locations for NP_001014338.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091995
    UniProtKB/Swiss-Prot
    Q58EB4
    UniProtKB/TrEMBL
    B2GQK9
    Related
    ENSDARP00000118435.1, ENSDART00000141548.2
    Conserved Domains (2) summary
    PRK05617
    Location:30 → 374
    PRK05617; 3-hydroxyisobutyryl-CoA hydrolase; Provisional
    pfam16113
    Location:43 → 371
    ECH_2; Enoyl-CoA hydratase/isomerase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    40874208..40924919
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q58EB4.1 GenPept UniProtKB/Swiss-Prot:Q58EB4

Gene LinkOut

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