Ceacam20 CEA cell adhesion molecule 20 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ceacam20provided by MGI
Official Full Name: CEA cell adhesion molecule 20provided by MGI
Primary source: MGI:MGI:1918851
See related: Ensembl:ENSMUSG00000070777 AllianceGenome:MGI:1918851
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9130012D09Rik
Summary: Involved in positive regulation of cytokine production. Acts upstream of or within response to bacterium. Located in apical plasma membrane and microvillus membrane. Orthologous to human CEACAM20 (CEA cell adhesion molecule 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 56.4), colon adult (RPKM 53.3) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 9.96 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (19699277..19725038)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (19965352..19991113)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gram-positive bacteria promote the mRNA expression of CEACAM1 or CEACAM20 in the small intestine. Inflammatory cytokines or butyrate likely participates in such effects of commensal bacteria.
Title: Regulation by gut commensal bacteria of carcinoembryonic antigen-related cell adhesion molecule expression in the intestinal epithelium.
SAP-1 and CEACAM20 thus constitute a regulatory system through which the intestinal epithelium contributes to intestinal immunity.
Title: Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: carcinoembryonic antigen-related cell adhesion molecule 20

Names: CEA-related cell adhesion molecule 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027839.2 → NP_082115.2 carcinoembryonic antigen-related cell adhesion molecule 20 precursor

See identical proteins and their annotated locations for NP_082115.2

Status: VALIDATED

Source sequence(s)

AC130530, AK033581, AV374496

Consensus CDS

CCDS20919.1

UniProtKB/Swiss-Prot

Q80Y42, Q9D2Z1

Related

ENSMUSP00000092344.5, ENSMUST00000094753.6

Conserved Domains (4) summary

smart00408
Location:163 → 219

IGc2; Immunoglobulin C-2 Type

smart00410
Location:158 → 232

IG_like; Immunoglobulin like

pfam13895
Location:342 → 418

Ig_2; Immunoglobulin domain

cl11960
Location:234 → 326

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

19699277..19725038

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006540360.2 → XP_006540423.1 carcinoembryonic antigen-related cell adhesion molecule 20 isoform X1

Conserved Domains (3) summary

smart00410
Location:344 → 416

IG_like; Immunoglobulin like

pfam13927
Location:160 → 217

Ig_3; Immunoglobulin domain

cl11960
Location:234 → 326

Ig; Immunoglobulin domain